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Title
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Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages.
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Authors
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A.Diefenbach,
A.M.Jamieson,
S.D.Liu,
N.Shastri,
D.H.Raulet.
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Ref.
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Nat Immunol, 2000,
1,
119-126.
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PubMed id
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Abstract
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Natural killer (NK) cells attack tumor and infected cells, but the receptors and
ligands that stimulate them are poorly understood. Here we report the expression
cloning of two murine ligands for the lectin-like receptor NKG2D. The two
ligands, H-60 and Rae1 beta, are distant relatives of major histocompatibility
complex class I molecules. NKG2D ligands are not expressed by most normal cells
but are up-regulated on numerous tumor cells. We show that mouse NKG2D is
expressed by NK cells, activated CD8+ T cells and activated macrophages.
Expression of either NKG2D ligand by target cells triggers NK cell cytotoxicity
and interferon-gamma secretion by NK cells, as well as nitric oxide release and
tumor necrosis factor alpha transcription by macrophages. Thus, through their
interaction with NKG2D, H-60 and Rae1 beta are newly identified potent
stimulators of innate immunity.
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