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Title
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Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.
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Authors
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A.Cerwenka,
A.B.Bakker,
T.McClanahan,
J.Wagner,
J.Wu,
J.H.Phillips,
L.L.Lanier.
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Ref.
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Immunity, 2000,
12,
721-727.
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PubMed id
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Abstract
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Here we describe a family of GPI-anchored cell surface proteins that function as
ligands for the mouse activating NKG2D receptor. These molecules are encoded by
the retinoic acid early inducible (RAE-1) and H60 minor histocompatibility
antigen genes on mouse chromosome 10 and show weak homology with MHC class I.
Expression of the NKG2D ligands is low or absent on normal, adult tissues;
however, they are constitutively expressed on some tumors and upregulated by
retinoic acid. Ectopic expression of RAE-1 and H60 confers target susceptibility
to NK cell attack. These studies identify a family of ligands for the activating
NKG2D receptor on NK and T cells, which may play an important role in innate and
adaptive immunity.
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