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Title
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Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site.
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Authors
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S.G.Sarafianos,
K.Das,
J.Ding,
P.L.Boyer,
S.H.Hughes,
E.Arnold.
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Ref.
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Chem Biol, 1999,
6,
R137.
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PubMed id
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Abstract
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Comparison of the recently solved structure of HIV-1 reverse transcriptase
(RT)-DNA-dNTP ternary complex with the previously solved structure of RT-DNA
binary complex suggests mechanisms by which the HIV-1 RT becomes resistant to
nucleoside-analog inhibitors, drugs currently used in the treatment of AIDS.
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