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Pfam domain PF00621

Pfam domain PF00621

Pfam domain:   
  PF00621 - RhoGEF domain  

Below is the list of protein structures in the PDB containing Pfam domain PF00621.

+/- Key to table

Structures in the PDB containing this domain: 166

  Pfam domain
architecture
UniProt
accession
UniProt id Protein name PDB structures
1.
Q86VW2 ARHGP_HUMAN Rho guanine nucleotide exchange factor 25
2rgnB.
2.
C4LYV4 C4LYV4_ENTHI Putative uncharacterized protein {ECO:0000313|EMBL:EAL47674.1}
4gouA.
3.
Q91X46 ARHG3_MOUSE Rho guanine nucleotide exchange factor 3
2z0qA.
4.
Q7Z628 ARHG8_HUMAN Neuroepithelial cell-transforming gene 1 protein
3eo2A.
5.
O55043 ARHG7_RAT Rho guanine nucleotide exchange factor 7
2ak5A, 2df6A, 2g6fX, 2p4rA, 2w6bA, 3l4fA.
6.
Q9QX73 ARHG9_RAT Rho guanine nucleotide exchange factor 9
2dfkA, 4mt6A, 4mt7A.
 
O43307 ARHG9_HUMAN Rho guanine nucleotide exchange factor 9
2ysqA.
 
Q9NR80 ARHG4_HUMAN Rho guanine nucleotide exchange factor 4
2dx1A, 2pz1A, 3nmxD, 3nmzD.
7.
Q92888 ARHG1_HUMAN Rho guanine nucleotide exchange factor 1
1iapA, 1shzC, 3ab3B, 3odoA, 3odwA, 3odxA, 3p6aA.
8.
Q9H8V3 ECT2_HUMAN Protein ECT2
3l46A, 4n40A.
 
Q07139 ECT2_MOUSE Protein ECT2
2couA.
9.
Q5VV41 ARHGG_HUMAN Rho guanine nucleotide exchange factor 16
1x6bA.
10.
Q9ES67 ARHGB_RAT Rho guanine nucleotide exchange factor 11
3cx6B, 3cx7B, 3cx8B.
11.
Q14155 ARHG7_HUMAN Rho guanine nucleotide exchange factor 7
1by1A, 1zsgA, 2l3gA.
 
Q9ES28 ARHG7_MOUSE Rho guanine nucleotide exchange factor 7
2eswA.
12.
Q15052 ARHG6_HUMAN Rho guanine nucleotide exchange factor 6
1ujyA, 1wyrA.
 
Q8K4I3 ARHG6_MOUSE Rho guanine nucleotide exchange factor 6
1v61A.
13.
Q69ZL1 FGD6_MOUSE FYVE, RhoGEF and PH domain-containing protein 6
1wgqA.
14.
Q60610 TIAM1_MOUSE T-lymphoma invasion and metastasis-inducing protein 1
1foeA, 3a8nA.
15.
Q8TCU6 PREX1_HUMAN Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
3qikA.
16.
Q07889 SOS1_HUMAN Son of sevenless homolog 1
1aweA, 1bkdS, 1dbhA, 1nvuS, 1nvvS, 1nvwS, 1nvxS, 1q9cA, 1xd2C, 1xd4A, 1xdvA, 3ksyA, 4nyiS, 4nyjS, 4nymS.
 
Q62245 SOS1_MOUSE Son of sevenless homolog 1
1gbqB, 1pmsA, 2gbqB, 3gbqB, 4gbqB.
 
Q02384 SOS2_MOUSE Son of sevenless homolog 2
1gbrB.
17.
P11274 BCR_HUMAN Breakpoint cluster region protein (E.C. 2.7.11.1)
1k1fA.
18.
Q6ZPF3 TIAM2_MOUSE T-lymphoma invasion and metastasis-inducing protein 2
3a8pA, 3a8qA.
19.
O15085 ARHGB_HUMAN Rho guanine nucleotide exchange factor 11
1htjF, 1xcgA, 2dlsA, 3kz1A, 3t06A.
20.
Q9NZN5 ARHGC_HUMAN Rho guanine nucleotide exchange factor 12
1txdA, 1x86A, 2omjA, 2os6A.
21.
Q6ZNL6 FGD5_HUMAN FYVE, RhoGEF and PH domain-containing protein 5
3mpxA.
22.
P11433 CDC24_YEAST Cell division control protein 24
1pqsA, 1q1oA, 1tz1A, 2kfjA, 2kfkB.
23.
Q13009 TIAM1_HUMAN T-lymphoma invasion and metastasis-inducing protein 1
2d8iA, 3kzdA, 3kzeA, 4gvcA, 4gvdA, 4k2oA, 4k2pA.
24.
Q5JSP0 FGD3_HUMAN FYVE, RhoGEF and PH domain-containing protein 3
2cocA.
25.
Q64096 MCF2L_MOUSE Guanine nucleotide exchange factor DBS
1kz7A, 1kzgA, 1lb1A, 1rj2A.
26.
P15498 VAV_HUMAN Proto-oncogene vav
2crhA, 2lctA, 2mc1A, 2rorA, 3bjiA, 3ky9A.
27.
Q9UKW4 VAV3_HUMAN Guanine nucleotide exchange factor VAV3
2d86A.
 
P52735 VAV2_HUMAN Guanine nucleotide exchange factor VAV2
2dlzA, 2dm1A, 2lnwA, 2lnxA, 4rojA.
28.
Q91VS8 FARP2_MOUSE FERM, RhoGEF and pleckstrin domain-containing protein 2
4gyvA, 4gzuA.
29.
P27870 VAV_MOUSE Proto-oncogene vav
1f5xA, 1gcpA, 1gcqC, 1k1zA, 2kbtA, 2vrwB.
30.
Q12802 AKP13_HUMAN A-kinase anchor protein 13
2drnC, 2lg1A, 4d0nB, 4d0oA.
31.
Q9Y4F1 FARP1_HUMAN FERM, RhoGEF and pleckstrin domain-containing protein 1
4h6yA.
32.
Q9Z0R4 ITSN1_MOUSE Intersectin-1
3hs8P, 3jv3A.
33.
Q15811 ITSN1_HUMAN Intersectin-1
1ki1B, 2kgrA, 2khnA, 3fiaA, 3qbvB, 4iimA.
34.
Q6XZF7 DNMBP_HUMAN Dynamin-binding protein
1ug1A, 1uhcA, 4cc2A, 4cc3A, 4cc4B, 4cc7A, 4glmA.
35.
Q9NZM3 ITSN2_HUMAN Intersectin-2
1j3tA, 1udlA, 1ue9A, 1uffA, 1uhfA, 3gf9A, 3jzyA, 4iioA.
36.
O75962 TRIO_HUMAN Triple functional domain protein (E.C. 2.7.11.1)
1ntyA, 2nz8B.
37.
A2CG49 KALRN_MOUSE Kalirin (E.C. 2.7.11.1)
1wfwA.
 
P97924 KALRN_RAT Kalirin (E.C. 2.7.11.1)
1u3oA, 2kr9A.
38.
O01761 UNC89_CAEEL Muscle M-line assembly protein unc-89
1fhoA.
39.
Q5VST9 OBSCN_HUMAN Obscurin (E.C. 2.7.11.1)
1v1cA, 2cr6A, 2dkuA, 2dm7A, 2e7bA, 2edfA, 2edhA, 2edlA, 2edqA, 2edrA, 2edtA, 2edwA, 2enyA, 2eo1A, 2gqhA, 2yz8A, 4c4kO, 4uow1.

List of Pfam domains

  Pfam code Pfam id Description
PF00621 RhoGEF RhoGEF domain
PF00017 SH2 SH2 domain
PF00018 SH3_1 SH3 domain
PF00041 fn3 Fibronectin type III domain
PF00069 Pkinase Protein kinase domain
PF00125 Histone Core histone H2A/H2B/H3/H4
PF00130 C1_1 Phorbol esters/diacylglycerol binding domain (C1 domain)
PF00168 C2 C2 domain
PF00169 PH PH domain
PF00307 CH Calponin homology (CH) domain
PF00373 FERM_M FERM central domain
PF00435 Spectrin Spectrin repeat
PF00533 BRCT BRCA1 C Terminus (BRCT) domain
PF00595 PDZ PDZ domain (Also known as DHR or GLGF)
PF00610 DEP Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PF00612 IQ IQ calmodulin-binding motif
PF00615 RGS Regulator of G protein signaling domain
PF00617 RasGEF RasGEF domain
PF00618 RasGEF_N RasGEF N-terminal motif
PF00620 RhoGAP RhoGAP domain
PF01363 FYVE FYVE zinc finger
PF02196 RBD Raf-like Ras-binding domain
PF03114 BAR BAR domain
PF05177 RCSD RCSD region
PF06395 CDC24 CDC24 Calponin
PF07653 SH3_2 Variant SH3 domain
PF07679 I-set Immunoglobulin I-set domain
PF08736 FA FERM adjacent (FA)
PF09036 Bcr-Abl_Oligo Bcr-Abl oncoprotein oligomerisation domain
PF09128 RGS-like Regulator of G protein signalling-like domain
PF09379 FERM_N FERM N-terminal domain
PF09380 FERM_C FERM C-terminal PH-like domain
PF11971 CAMSAP_CH CAMSAP CH domain
PF12738 PTCB-BRCT twin BRCT domain
PF12763 EF-hand_4 Cytoskeletal-regulatory complex EF hand
PF13716 CRAL_TRIO_2 Divergent CRAL/TRIO domain
PF14604 SH3_9 Variant SH3 domain
PF15405 PH_5 Pleckstrin homology domain
PF15411 PH_10 Pleckstrin homology domain
PB001367
PB002518
PB004193
PB004195
PB004447
PB005209
PB006000
PB006687
PB006814
PB007098
PB007809
PB009624
PB009735
PB010393
PB011501
PB011703
PB012211
PB012350
PB013461
PB013592
PB015024
PB015253
PB015576
PB015640
PB017599
PB018723
PB020210
PB020329
PB021496
PB021899
PB022245
PB022492
PB023322
PB023462
PB023550
PB026270
PB029784
PB031216
PB033677
PB035358
PB035897
PB038958
PB044547
PB045785
PB046440
PB047353
PB047372
PB093916
PB095564
PB1
PB111446
PB111563
PB136136
PB147442

 

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