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Pfam domain PF00378

Pfam domain PF00378

Pfam domain:   
  PF00378 - Enoyl-CoA hydratase/isomerase family  

Below is the list of protein structures in the PDB containing Pfam domain PF00378.

+/- Key to table

Structures in the PDB containing this domain: 165

  Pfam domain
architecture
UniProt
accession
UniProt id Protein name PDB structures
1.
A0QBQ2 A0QBQ2_MYCA1 Enoyl-CoA hydratase {ECO:0000313|EMBL:ABK64984.1}
3oc7A.
 
A0QFV0 A0QFV0_MYCA1 Carnitinyl-CoA dehydratase {ECO:0000313|EMBL:ABK66468.1} (E.C. 4.2.1.- {ECO:0000313|EMBL:ABK66468.1})
3r0oA.
 
A0QFV4 A0QFV4_MYCA1 Enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:ABK67429.1}
3p5mA.
 
A0QC84 A0QC84_MYCA1 Carnitinyl-CoA dehydratase {ECO:0000313|EMBL:ABK65107.1} (E.C. 4.2.1.- {ECO:0000313|EMBL:ABK65107.1})
3r9sA.
 
A0QIX8 A0QIX8_MYCA1 Enoyl-CoA hydratase {ECO:0000313|EMBL:ABK66089.1}
3p85A.
 
Q2G8B7 Q2G8B7_NOVAD Short chain enoyl-CoA hydratase {ECO:0000313|EMBL:ABD25906.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:ABD25906.1})
4jwvA.
 
A0QS88 A0QS88_MYCS2 Enoyl-CoA hydratase {ECO:0000313|EMBL:ABK70216.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:AFP37825.1})
4qfeA.
 
A0QST4 A0QST4_MYCS2 Enoyl-CoA hydratase {ECO:0000313|EMBL:ABK72311.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:AFP38027.1})
3mybA.
 
A0QVP0 A0QVP0_MYCS2 Enoyl-CoA hydratase {ECO:0000313|EMBL:ABK71224.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:AIU07816.1})
3pe8A.
 
A0R1R4 A0R1R4_MYCS2 Enoyl-CoA hydratase {ECO:0000313|EMBL:AIU09893.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:AIU09893.1}, 4.2.1.17 {ECO:0000313|EMBL:ABK71507.1})
3omeA.
 
A0R747 A0R747_MYCS2 Enoyl-CoA hydratase {ECO:0000313|EMBL:AFP43021.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:AFP43021.1}, 4.2.1.17 {ECO:0000313|EMBL:ABK73095.1})
3moyA.
 
A1RAA6 A1RAA6_ARTAT Enoyl-CoA hydratase/isomerase family protein {ECO:0000313|EMBL:ABM09998.1}
4mouA.
 
A1U4G2 A1U4G2_MARHV Enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:ABM19881.1}
4k3wA.
 
A3M7S1 A3M7S1_ACIBT Putative enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:ABO12965.2}
3fduA.
 
A4XEF6 A4XEF6_NOVAD Enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:ABP64317.1}
4wczA.
 
A5JTM5 CBADH_PSEUC 4-chlorobenzoyl coenzyme A dehalogenase {ECO:0000303|PubMed:7579994} (E.C. 3.8.1.7)
1jxzA, 1nzyA.
 
A7IKN6 A7IKN6_XANP2 Enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:ABS68579.1}
4k29A.
 
A0QIL3 A0QIL3_MYCA1 Enoyl-CoA hydratase {ECO:0000313|EMBL:ABK64508.1}
3q1tA.
 
B1GB42 B1GB42_9BURK Enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:EDT06643.1}
4kd6A.
 
B1MC45 B1MC45_MYCA9 Probable enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:CAM62816.1}
3sllA.
 
B1MEE0 B1MEE0_MYCA9 Probable enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:CAM60204.1}
3qxzA.
 
B1MGI6 B1MGI6_MYCA9 Probable enoyl-coa hydratase/isomerase {ECO:0000313|EMBL:CAM63931.1}
3r9qA.
 
B1MIA8 B1MIA8_MYCA9 Putative enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:CAM60930.1}
3rsiA.
 
B1MJ43 B1MJ43_MYCA9 Putative enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:CAM60999.1}
4mi2A.
 
B1ML12 B1ML12_MYCA9 Probable enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:CAM64657.1}
3trrA.
 
B1MM02 B1MM02_MYCA9 Probable enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:CAM61579.1}
3swxA.
 
B2HD64 B2HD64_MYCMM Enoyl-CoA hydratase, EchA8_6 {ECO:0000313|EMBL:ACC41201.1}
3qmjA.
 
B2HHI0 B2HHI0_MYCMM Enoyl-CoA hydratase EchA17 {ECO:0000313|EMBL:ACC40112.1}
4di1A.
 
B2HI06 B2HI06_MYCMM Enoyl-CoA hydratase EchA19 {ECO:0000313|EMBL:ACC43406.1}
4f47A.
 
B2HM22 B2HM22_MYCMM Enoyl-CoA hydratase EchA15 {ECO:0000313|EMBL:ACC40486.1}
3qk8A.
 
B2HMZ1 B2HMZ1_MYCMM Enoyl-CoA hydratase EchA1 {ECO:0000313|EMBL:ACC38930.1}
3qxiA.
 
B2HQD1 B2HQD1_MYCMM Enoyl-CoA hydratase, EchA12_1 {ECO:0000313|EMBL:ACC42423.1}
3qreA.
 
B2HSG1 B2HSG1_MYCMM Enoyl-CoA hydratase, EchA3 {ECO:0000313|EMBL:ACC39419.1}
3r6hA.
 
B2HSK3 B2HSK3_MYCMM Enoyl-CoA hydratase, EchA5 {ECO:0000313|EMBL:ACC39461.1}
3qkaA.
 
G3XAQ0 G3XAQ0_MYCTH probable enoyl-COA hydratase {ECO:0000313|PDB:3T3W}
3t3wA.
 
Q82Q85 Q82Q85_STRAW Putative enoyl-CoA hydratase {ECO:0000313|EMBL:BAC68345.1}
3h0uA.
 
Q82QL3 Q82QL3_STRAW Putative enoyl-CoA hydratase {ECO:0000313|EMBL:BAC68202.1}
3gkbA.
 
Q884M3 Q884M3_PSESM Enoyl-CoA hydratase/isomerase family protein {ECO:0000313|EMBL:AAO55583.1}
3ot6A.
 
O69762 HCHL_PSEFL Hydroxycinnamoyl-CoA hydratase-lyase (E.C. 4.1.2.41, 4.2.1.101)
2j5iA, 2vssA, 2vsuA.
 
Q8GGP6 Q8GGP6_STRAZ Putative enoyl-CoA hydratase {ECO:0000313|EMBL:AAN85519.1}
4nnqA.
 
Q8KLK7 Q8KLK7_STRTO DpgC {ECO:0000313|EMBL:AAM80546.1}
2np9A, 2pg8A.
 
P0ABU0 MENB_ECOLI 1,4-dihydroxy-2-naphthoyl-CoA synthase {ECO:0000255|HAMAP-Rule:MF_01934, ECO:0000303|PubMed:21830810} (E.C. 4.1.3.36 {ECO:0000255|HAMAP-Rule:MF_01934, ECO:0000269|PubMed:20643650, ECO:0000269|PubMed:21830810, ECO:0000269|PubMed:22606952, ECO:0000269|PubMed:23658663})
3t88A, 3t89A, 4elsA, 4elwA, 4elxA, 4i42A.
 
P14604 ECHM_RAT Enoyl-CoA hydratase, mitochondrial (E.C. 4.2.1.17)
1dubA, 1ey3A, 1mj3A, 2dubA.
 
P23965 ECI1_RAT Enoyl-CoA delta isomerase 1, mitochondrial (E.C. 5.3.3.8)
1xx4A.
 
Q93TU6 CAMK_RHOSO 6-oxocamphor hydrolase (E.C. 3.7.1.18)
1o8uA, 1szoA.
 
A8H6D2 A8H6D2_SHEPA Enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:ABV88119.1}
4kpkA.
 
P40805 PKSH_BACSU Probable polyketide biosynthesis enoyl-CoA hydratase PksH (E.C. 4.2.1.-)
3hp0A.
 
P42126 ECI1_HUMAN Enoyl-CoA delta isomerase 1, mitochondrial (E.C. 5.3.3.8)
1sg4A.
 
P52045 SCPB_ECOLI Methylmalonyl-CoA decarboxylase (E.C. 4.1.1.41)
1ef8A, 1ef9A.
 
P73495 P73495_SYNY3 Naphthoate synthase {ECO:0000313|EMBL:BAA17535.1}
4emlA, 4i4zA, 4i52A.
 
P76082 PAAF_ECOLI 2,3-dehydroadipyl-CoA hydratase (E.C. 4.2.1.17)
4fzwA.
 
P77467 PAAG_ECOLI 1,2-epoxyphenylacetyl-CoA isomerase (E.C. 5.3.3.18)
4fzwC.
 
P83702 P83702_THETH Enoyl-CoA hydratase {ECO:0000313|PDB:1UIY}
1uiyA.
 
P96907 P96907_MYCTX Enoyl-CoA hydratase {ECO:0000313|EMBL:AID03704.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:KFC56648.1})
4fn7A, 4fn8A, 4fnbA, 4fndA, 4hc8A.
 
Q05871 ECI1_YEAST 3,2-trans-enoyl-CoA isomerase (E.C. 5.3.3.8)
1hnoA, 1hnuA, 1k39A, 1pjhA.
 
Q0C365 Q0C365_HYPNA Enoyl-CoA hydratase/isomerase family protein {ECO:0000313|EMBL:ABI76967.1}
4olqA.
 
Q129C0 Q129C0_POLSJ Enoyl-CoA hydratase {ECO:0000313|EMBL:ABE44872.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:ABE44872.1})
4jfcA.
 
Q13011 ECH1_HUMAN Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (E.C. 5.3.3.-)
2vreA.
 
Q13825 AUHM_HUMAN Methylglutaconyl-CoA hydratase, mitochondrial (E.C. 4.2.1.18)
1hzdA, 2zqqA, 2zqrA.
 
Q7CQ56 MENB_SALTY 1,4-dihydroxy-2-naphthoyl-CoA synthase {ECO:0000255|HAMAP-Rule:MF_01934} (E.C. 4.1.3.36 {ECO:0000255|HAMAP-Rule:MF_01934})
3h02A.
 
Q1LBW6 Q1LBW6_RALME Enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:ABF12360.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:ABF12360.1})
4jcsA.
 
Q81L70 Q81L70_BACAN 3-hydroxypropionyl-coenzyme A dehydratase {ECO:0000313|EMBL:AIK31844.1} (E.C. 4.2.1.116 {ECO:0000313|EMBL:AIK31844.1})
3peaA.
 
Q2GB08 Q2GB08_NOVAD Enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:ABD24965.1}
4jyjA.
 
Q2GB23 Q2GB23_NOVAD Enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:ABD24950.1}
4og1A.
 
Q2VZN8 Q2VZN8_MAGSA Enoyl-CoA hydratase/carnithine racemase {ECO:0000313|EMBL:BAE52937.1}
4nekA.
 
Q2W7Q6 Q2W7Q6_MAGSA Enoyl-CoA hydratase/carnithine racemase {ECO:0000313|EMBL:BAE50119.1}
4k2nA.
 
Q73VV7 Q73VV7_MYCPA EchA16_2 {ECO:0000313|EMBL:AAS05221.1}
3qyrA.
 
Q47NQ8 Q47NQ8_THEFY Enoyl-CoA hydratase {ECO:0000313|EMBL:AAZ55911.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:AAZ55911.1})
4jsbA, 4jvtA, 4omrA.
 
Q5HH38 MENB_STAAC 1,4-dihydroxy-2-naphthoyl-CoA synthase {ECO:0000255|HAMAP-Rule:MF_01934} (E.C. 4.1.3.36 {ECO:0000255|HAMAP-Rule:MF_01934})
2uzfA.
 
Q5KVX8 Q5KVX8_GEOKA Dihydroxynapthoic acid synthetase {ECO:0000313|EMBL:BAD77158.1} (E.C. 4.1.3.36 {ECO:0000313|EMBL:BAD77158.1})
2iexA.
 
Q5KYB2 Q5KYB2_GEOKA Enoyl-CoA hydratase subunit I (Phenylacetic acid catabolism) {ECO:0000313|EMBL:BAD76324.1}
2pbpA, 2qq3A.
 
Q5KYB3 Q5KYB3_GEOKA Enoyl-CoA hydratase subunit II (Phenylacetic acid catabolism) {ECO:0000313|EMBL:BAD76323.1}
2ej5A.
 
Q5KYF9 Q5KYF9_GEOKA Enoyl-CoA hydratase {ECO:0000313|EMBL:BAD76277.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:BAD76277.1})
2ppyA.
 
Q5LQZ3 Q5LQZ3_RUEPO Enoyl-CoA hydratase/isomerase family protein {ECO:0000313|EMBL:AAV95601.2}
3l3sA.
 
Q5SLK3 Q5SLK3_THET8 Probable enoyl-CoA hydratase {ECO:0000313|EMBL:BAD70113.1}
3gowA, 3hrxA.
 
Q5SLS5 Q5SLS5_THET8 Enoyl-CoA hydratase {ECO:0000313|EMBL:BAD70041.1}
1wz8A.
 
Q5ZUH0 Q5ZUH0_LEGPH Enoyl CoA hydratase/isomerase (Crotonase) {ECO:0000313|EMBL:AAU27907.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:AAU27907.1})
3i47A.
 
Q62651 ECH1_RAT Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (E.C. 5.3.3.-)
1dciA.
 
Q9XB60 CARB_PECCC Carboxymethylproline synthase {ECO:0000303|PubMed:15595850} (E.C. 2.3.1.226 {ECO:0000269|PubMed:14625287, ECO:0000269|PubMed:15595850})
2a7kA, 2a81A.
 
Q6N8W7 Q6N8W7_RHOPA Putative 3-hydroxybutyryl-CoA dehydratase {ECO:0000313|EMBL:CAE27227.1} (E.C. 4.2.1.55 {ECO:0000313|EMBL:CAE27227.1})
3hinA.
 
P30084 ECHM_HUMAN Enoyl-CoA hydratase, mitochondrial (E.C. 4.2.1.17)
2hw5A.
 
Q73WL5 Q73WL5_MYCPA EchA1_1 {ECO:0000313|EMBL:AAS04962.1}
3r9tA.
 
Q73WM1 Q73WM1_MYCPA EchA11 {ECO:0000313|EMBL:AAS04956.1}
4lk5A.
 
Q73XB1 Q73XB1_MYCPA Uncharacterized protein {ECO:0000313|EMBL:AAS04715.1}
3tlfA.
 
Q742C8 Q742C8_MYCPA EchA7 {ECO:0000313|EMBL:AAS03226.1}
4knpA.
 
Q743A2 Q743A2_MYCPA Uncharacterized protein {ECO:0000313|EMBL:AAS03000.1}
3rrvA.
 
Q7CLS3 Q7CLS3_XANCP RpfF protein {ECO:0000313|EMBL:AAM41146.1}
3m6mA, 3m6nA.
 
Q81Q82 Q81Q82_BACAN Enoyl-CoA hydratase {ECO:0000313|EMBL:AIF56742.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:AIF56742.1})
3kqfA.
 
Q7W3D6 Q7W3D6_BORPA Putative enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:CAE39387.1}
3isaA.
 
Q9I498 Q9I498_PSEAE Probable enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:AAG04629.1}
3laoA.
 
Q9RY37 Q9RY37_DEIRA Enoyl-CoA hydratase, putative {ECO:0000313|EMBL:AAF09706.1}
4jotA.
 
Q93JE8 Q93JE8_STRCO Putative enoyl-CoA hydratase {ECO:0000313|EMBL:CAC44593.1}
3g64A.
 
Q9KBS5 Q9KBS5_BACHD Enoyl-CoA hydratase {ECO:0000313|EMBL:BAB05568.1}
3lkeA.
 
Q97CA4 Q97CA4_THEVO Enoyl-CoA hydratase {ECO:0000313|EMBL:BAB59340.1}
4jylA.
 
Q8YNV6 Q8YNV6_NOSS1 Alr4455 protein {ECO:0000313|EMBL:BAB76154.1}
2j5gA, 2j5sA.
2.
Q96DC8 ECHD3_HUMAN Enoyl-CoA hydratase domain-containing protein 3, mitochondrial
2vx2A.
3.
Q13WK7 Q13WK7_BURXL 2,3-dihydro-2,3-dihydroxybenzoyl-CoA ring cleavage enzyme {ECO:0000313|EMBL:ABE31532.1}
2w3pA.
4.
A0QS86 A0QS86_MYCS2 Enoyl-CoA hydratase {ECO:0000313|EMBL:ABK76145.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:AIU06627.1}, 4.2.1.17 {ECO:0000313|EMBL:AFP37823.1})
3njbA, 3njdA.
5.
G7CC99 G7CC99_MYCTH 3-hydroxyisobutyryl-CoA hydrolase {ECO:0000313|EMBL:EHI14362.1}
4hdtA.
 
Q3J1K7 Q3J1K7_RHOS4 Enoyl-CoA hydratase {ECO:0000313|EMBL:ABA79327.1} (E.C. 4.2.1.17 {ECO:0000313|EMBL:ABA79327.1})
4j2uA.
 
Q8EGC3 Q8EGC3_SHEON 3-hydroxyisobutyryl-CoA hydrolase IvdE {ECO:0000313|EMBL:AAN54736.1} (E.C. 3.1.2.4 {ECO:0000313|EMBL:AAN54736.1})
3ju1A.
6.
Q8N8U2 CDYL2_HUMAN Chromodomain Y-like protein 2
2mj8A, 4haeA.
7.
O75521 ECI2_HUMAN Enoyl-CoA delta isomerase 2, mitochondrial (E.C. 5.3.3.8)
2cquA, 2f6qA, 4u18A, 4u19A, 4u1aA.
8.
Q9Y232 CDYL1_HUMAN Chromodomain Y-like protein (E.C. 2.3.1.48)
2dntA, 2gtrA.
9.
Q9Y6F8 CDY1_HUMAN Testis-specific chromodomain protein Y 1 (E.C. 2.3.1.48)
2fbmA.
 
Q9Y6F7 CDY2_HUMAN Testis-specific chromodomain protein Y 2 (E.C. 2.3.1.48)
2fw2A.
10.
O53872 O53872_MYCTU 3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:AIR13593.1}
4b3hA, 4b3iA, 4b3jA.
11.
P28793 FADB_PSEFR Fatty acid oxidation complex subunit alpha {ECO:0000255|HAMAP-Rule:MF_01621} (E.C. 4.2.1.17 {ECO:0000255|HAMAP-Rule:MF_01621}, 5.1.2.3 {ECO:0000255|HAMAP-Rule:MF_01621}, 5.3.3.8 {ECO:0000255|HAMAP-Rule:MF_01621}, 1.1.1.35 {ECO:0000255|HAMAP-Rule:MF_01621})
1wdkA, 1wdlA, 1wdmA, 2d3tA.
12.
Q9ZPI5 MFP2_ARATH Peroxisomal fatty acid beta-oxidation multifunctional protein MFP2 (E.C. 4.2.1.17, 5.1.2.3, 5.3.3.8, 1.1.1.35)
2wtbA.
13.
P07896 ECHP_RAT Peroxisomal bifunctional enzyme (E.C. 4.2.1.17, 5.3.3.8, 1.1.1.35)
1zcjA, 2x58A, 3zw8A, 3zw9A, 3zwaA, 3zwbA, 3zwcA.
14.
O28011 O28011_ARCFU 3-hydroxyacyl-CoA dehydrogenase (Hbd-10) {ECO:0000313|EMBL:AAB88983.1}
3ctvA.
15.
Q6DNE7 Q6DNE7_9CYAN CurF {ECO:0000313|EMBL:AAT70101.1}
2q2xA, 2q34A, 2q35A, 3kg6A.

List of Pfam domains

  Pfam code Pfam id Description
PF00378 ECH Enoyl-CoA hydratase/isomerase family
PF00107 ADH_zinc_N Zinc-binding dehydrogenase
PF00109 ketoacyl-synt Beta-ketoacyl synthase, N-terminal domain
PF00385 Chromo Chromo (CHRromatin Organisation MOdifier) domain
PF00501 AMP-binding AMP-binding enzyme
PF00550 PP-binding Phosphopantetheine attachment site
PF00668 Condensation Condensation domain
PF00698 Acyl_transf_1 Acyl transferase domain
PF00725 3HCDH 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00887 ACBP Acyl CoA binding protein
PF02737 3HCDH_N 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02801 Ketoacyl-synt_C Beta-ketoacyl synthase, C-terminal domain
PF08240 ADH_N Alcohol dehydrogenase GroES-like domain
PF08415 NRPS Nonribosomal peptide synthase
PF13193 AMP-binding_C AMP-binding enzyme C-terminal domain
PF13766 ECH_C 2-enoyl-CoA Hydratase C-terminal region
PF14765 PS-DH Polyketide synthase dehydratase
PB008396
PB014969
PB017471
PB046075
PB047629
PB051834

 

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