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PDBsum entry 3tgs

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protein ligands Protein-protein interface(s) links
Viral protein PDB id
3tgs
Jmol
Contents
Protein chains
345 a.a.
Ligands
NAG ×13
03G ×2
Waters ×104
PDB id:
3tgs
Name: Viral protein
Title: Crystal structure of HIV-1 cladE C strain c1086 gp120 core i with nbd-556
Structure: HIV-1 clade c1086 gp120 core. Chain: a, b. Engineered: yes
Source: Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293.
Resolution:
2.70Å     R-factor:   0.242     R-free:   0.295
Authors: Y.D.Kwon,P.D.Kwong
Key ref: Y.D.Kwon et al. (2012). Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc Natl Acad Sci U S A, 109, 5663-5668. PubMed id: 22451932 DOI: 10.1073/pnas.1112391109
Date:
17-Aug-11     Release date:   04-Apr-12    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
C6G099  (C6G099_9HIV1) -  Envelope glycoprotein gp160
Seq:
Struc:
 
Seq:
Struc:
849 a.a.
345 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     viral envelope   1 term 

 

 
DOI no: 10.1073/pnas.1112391109 Proc Natl Acad Sci U S A 109:5663-5668 (2012)
PubMed id: 22451932  
 
 
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.
Y.D.Kwon, A.Finzi, X.Wu, C.Dogo-Isonagie, L.K.Lee, L.R.Moore, S.D.Schmidt, J.Stuckey, Y.Yang, T.Zhou, J.Zhu, D.A.Vicic, A.K.Debnath, L.Shapiro, C.A.Bewley, J.R.Mascola, J.G.Sodroski, P.D.Kwong.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22864288 Y.Mao, L.Wang, C.Gu, A.Herschhorn, S.H.Xiang, H.Haim, X.Yang, and J.Sodroski (2012).
Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer.
  Nat Struct Mol Biol, 19, 893-899.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.