|
|
 |
|
| PDB id |
|
Count |
|
Name |
|
Method |
|
Date |
|
|
|
|
×1
|
|
C-src (sh2 domain) complexed with ace-malonyl tyr-glu-(n,n-dipentyl amine)
|
|
X-ray(2.2Å)
|
|
08-Apr-98
|
|
|
|
×1
|
|
C-src (sh2 domain) complexed with ace-difluoro phosphotyr-glu-(n,n- dipentyl amine)
|
|
X-ray(2.2Å)
|
|
08-Apr-98
|
|
|
|
×1
|
|
C-src (sh2 domain) complexed with ace-formyl phosphotyr-glu-(n,n- dipentyl amine)
|
|
X-ray(2Å)
|
|
08-Apr-98
|
|
|
|
×1
|
|
C-src (sh2 domain with c188a mutation) complexed with ace-formyl phosphotyr-glu-(n,n-dipentyl amine)
|
|
X-ray(2Å)
|
|
08-Apr-98
|
|
|
|
×1
|
|
C-src (sh2 domain) complexed with ace-phosphotyr-glu-(n,n-dipentyl amine)
|
|
X-ray(2.2Å)
|
|
08-Apr-98
|
|
|
|
×1
|
|
C-src (sh2 domain) complexed with ace-phosphotyr-glu-(n-me(-(ch2)3- cyclopentyl))
|
|
X-ray(2.4Å)
|
|
08-Apr-98
|
|
|
|
×1
|
|
C-src (sh2 domain) complexed with ace-phosphotyr-glu-(3- butylpiperidine)
|
|
X-ray(2.2Å)
|
|
08-Apr-98
|
|
|
|
×0
|
|
Structure of thrombin inhibited by aeruginosin298-a from a blue-green alga
|
|
X-ray(2.1Å)
|
|
01-Jul-98
|
|
|
|
×0
|
|
HIV-1 protease complexed with a tripeptide inhibitor
|
|
X-ray(2Å)
|
|
29-Apr-98
|
|
|
|
×1
|
|
14-3-3 protein zeta bound to r18 peptide
|
|
X-ray(3.35Å)
|
|
02-Mar-99
|
|
|
|
×0
|
|
Thrombin complexed with hirugen and a beta-strand mimetic inhibitor
|
|
X-ray(2.12Å)
|
|
27-May-98
|
|
|
|
×0
|
|
Crystal structures of thrombin with thiazole-containing inhibitors: probes of the s1' binding site
|
|
X-ray(1.8Å)
|
|
29-Apr-98
|
|
|
|
×0
|
|
Human thrombin complexed with novel synthetic peptide mimetic inhibitor and hirugen
|
|
X-ray(2.06Å)
|
|
27-May-98
|
|
|
|
×0
|
|
Thrombin complexed with a beta-mimetic thiazole-containing inhibitor
|
|
X-ray(2.2Å)
|
|
17-Jun-98
|
|
|
|
×0
|
|
Complex of thrombin with and inhibitor containing a novel p1 moiety
|
|
X-ray(2Å)
|
|
12-Nov-97
|
|
|
|
×0
|
|
Human alpha-thrombin inhibition by eoc-d-phe-pro-azalys-onp
|
|
X-ray(2Å)
|
|
03-Dec-97
|
|
|
|
×0
|
|
Human alpha-thrombin inhibition by cbz-pro-azalys-onp
|
|
X-ray(2Å)
|
|
03-Dec-97
|
|
|
|
×0
|
|
Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 angstroms resolution
|
|
X-ray(1.6Å)
|
|
17-Mar-96
|
|
|
|
×0
|
|
Human alpha-thrombin ternary complex with the exosite inhibitor hirugen and active site inhibitor phch2oco-d-dpa-pro-borompg
|
|
X-ray(1.85Å)
|
|
15-Oct-97
|
|
|
|
×0
|
|
Human alpha-thrombin ternary complex with exosite inhibitor hirugen and active site inhibitor phch2oco-d-dpa-pro-boroval
|
|
X-ray(2.1Å)
|
|
15-Oct-97
|
|
|
|
×0
|
|
Complex of the human mhc class i glycoprotein hla-a2 and the t cell coreceptor cd8
|
|
X-ray(2.65Å)
|
|
17-Sep-97
|
|
|
|
×1
|
|
X11 ptb domain-10mer peptide complex
|
|
X-ray(2.3Å)
|
|
24-Dec-97
|
|
|
|
×0
|
|
Novel covalent thrombin inhibitor from plant extract
|
|
X-ray(2.2Å)
|
|
28-Oct-98
|
|
|
|
×0
|
|
Thrombin inhibitor from theonalla, cyclotheanamide-based macrocyclic tripeptide motif
|
|
X-ray(1.8Å)
|
|
18-Mar-98
|
|
|
|
×0
|
|
Crystal structures of peptide complexes of the amino-terminal sh2 domain of the syp tyrosine phosphatase
|
|
X-ray(3Å)
|
|
31-Aug-94
|
|
|
|
×0
|
|
Crk sh3 domain complexed with peptoid inhibitor
|
|
X-ray(2.5Å)
|
|
06-Jan-99
|
|
|
|
×0
|
|
Human thrombin complexed with novel synthetic peptide mimetic inhibitor and hirugen
|
|
X-ray(2.07Å)
|
|
27-May-98
|
|
|
|
×0
|
|
Thrombin inhibitor with a rigid tripeptidyl aldehydes
|
|
X-ray(1.8Å)
|
|
27-Apr-99
|
|
|
|
×0
|
|
Thrombin inhibitors with rigid tripeptidyl aldehydes
|
|
X-ray(2.1Å)
|
|
27-Apr-99
|
|
|
|
×0
|
|
Chemotaxis receptor recognition by protein methyltransferase cher
|
|
X-ray(2.2Å)
|
|
25-Nov-98
|
|
|
|
×0
|
|
Alpha-thrombin complexed with hirugen and proflavin
|
|
X-ray(2Å)
|
|
14-Oct-98
|
|
|
|
×0
|
|
Glutamate dehydrogenase
|
|
X-ray(1.9Å)
|
|
14-Oct-98
|
|
|
|
×0
|
|
P56lck sh2 domain inhibitor complex
|
|
X-ray(1.8Å)
|
|
21-Oct-98
|
|
|
|
×0
|
|
X-ray structure of the complex of human alpha thrombin with the inhibitor sdz 229-357
|
|
X-ray(2.3Å)
|
|
04-Nov-98
|
|
|
|
×0
|
|
Grb2-sh2 domain in complex with kpfy Vnvef (pkf270-974)
|
|
X-ray(1.8Å)
|
|
29-Jul-98
|
|
|
|
×0
|
|
Human alpha-thrombin complexed with [s-(r ,R )]-4-[(Aminoiminomethyl) amino]-n-[[1-[3-hydroxy-2-[(2-naphthalenylsulfonyl)amino]-1- oxopropyl]-2-pyrrolidinyl] methyl]butanamide (bms-186282)
|
|
X-ray(2.6Å)
|
|
07-Dec-96
|
|
|
|
×0
|
|
Human alpha-thrombin complexed with [s-(r ,R )]-1-(Aminoiminomethyl)- n-[[1-[n-[(2-naphthalenylsulfonyl)-l-seryl]-pyrrolidinyl]methyl]-3- piperidenecarboxamide (bms-189090)
|
|
X-ray(2.8Å)
|
|
07-Dec-96
|
|
|
|
×0
|
|
E2-c, an ubiquitin conjugating enzyme required for the destruction of mitotic cyclins
|
|
X-ray(2Å)
|
|
02-Sep-98
|
|
|
|
×0
|
|
Cyclic peptide inhibitor of human ptp1b
|
|
X-ray(2.1Å)
|
|
16-Feb-99
|
|
|
|
×0
|
|
The structures of the cysteine proteases cathepsins k and s deduced by knowledge-based modelling, theoretical model
|
|
Theor. model
|
|
18-Oct-99
|
|
|
|
×0
|
|
Selective non electrophilic thrombin inhibitors with cyclohexyl moieties.
|
|
X-ray(2.1Å)
|
|
27-Sep-00
|
|
|
|
×0
|
|
Selective non electrophilic thrombin inhibitors with cyclohexyl moieties.
|
|
X-ray(2.1Å)
|
|
27-Sep-00
|
|
|
|
×0
|
|
Selective non-electrophilic thrombin inhibitors
|
|
X-ray(2.7Å)
|
|
09-Oct-00
|
|
|
|
×0
|
|
Structural basis for selectivity of a small molecule, s1-binding, sub- micromolar inhibitor of urokinase type plasminogen activator
|
|
X-ray(1.47Å)
|
|
22-Dec-00
|
|
|
|
×0
|
|
Structural basis for selectivity of a small molecule, s1-binding, sub- micromolar inhibitor of urokinase type plasminogen activator
|
|
X-ray(1.5Å)
|
|
22-Dec-00
|
|
|
|
×2
|
|
Peptide-in-groove interactions link target proteins to the b-propeller of clathrin
|
|
X-ray(2.9Å)
|
|
07-Feb-00
|
|
|
|
×0
|
|
Thrombin inhibitors with rigid tripeptidyl aldehydes
|
|
X-ray(2.1Å)
|
|
27-Apr-99
|
|
|
|
×2
|
|
Structure of tnf receptor associated factor 2 in complex with a peptide from tnf-r2
|
|
X-ray(2.3Å)
|
|
12-Apr-99
|
|
|
|
×5
|
|
Crystal structure of bovine liver glutamate dehydrogenase complexed with gtp, nadh, and l-glutamic acid
|
|
X-ray(2.9Å)
|
|
09-Apr-99
|
|
|
|
×0
|
|
Solution structure of cggirgera in contact with the monoclonal antibody mab 4x11, nmr, 7 structures
|
|
NMR(7 models)
|
|
02-Sep-99
|
|
|
|
×0
|
|
Syk tyrosine kinasE C-terminal sh2 domain complexed with a phosphopeptidefrom the gamma chain of the high affinity immunoglobin g receptor, nmr
|
|
NMR(20 models)
|
|
08-Nov-96
|
|
|
|
×0
|
|
Syk tyrosine kinasE C-terminal sh2 domain complexed with a phosphopeptidefrom the gamma chain of the high affinity immunoglobin g receptor, nmr
|
|
NMR(1 model)
|
|
08-Nov-96
|
|
|
|
×0
|
|
Solution structure of cggirgerg in contact with the monoclonal antibody mab 4x11, nmr, 11 structures
|
|
NMR(11 models)
|
|
02-Sep-99
|
|
|
|
×0
|
|
Human p56lck tyrosine kinase complexed with phosphopeptide
|
|
X-ray(2.25Å)
|
|
07-Dec-96
|
|
|
|
×2
|
|
Human p56lck tyrosine kinase complexed with phosphopeptide
|
|
X-ray(2.3Å)
|
|
07-Dec-96
|
|
|
|
×1
|
|
Structure of tnf receptor associated factor 2 in complex with a 17- residue cd40 peptide
|
|
X-ray(2.7Å)
|
|
08-Mar-00
|
|
|
|
×7
|
|
Structure of tnf receptor associated factor 2 in complex with a 5- residue cd40 peptide
|
|
X-ray(2Å)
|
|
29-Mar-00
|
|
|
|
×6
|
|
Structure of tnf receptor associated factor 2 in complex with a human cd30 peptide
|
|
X-ray(2Å)
|
|
02-Dec-03
|
|
|
|
×10
|
|
Structure of tnf receptor associated factor 2 (traf2) in complex with a human ox40 peptide
|
|
X-ray(2Å)
|
|
08-Mar-00
|
|
|
|
×8
|
|
Structure of tnf receptor associated factor 2 in complex with a m4-1bb peptide
|
|
X-ray(2.5Å)
|
|
08-Mar-00
|
|
|
|
×0
|
|
Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at p1
|
|
X-ray(2Å)
|
|
25-Oct-00
|
|
|
|
×0
|
|
Structure of thrombin complexed with selective non-electophilic inhibitors having cyclohexyl moieties at p1
|
|
X-ray(2.3Å)
|
|
30-Oct-00
|
|
|
|
×0
|
|
Crystal structure of the complex between the leech carboxypeptidase inhibitor and the human carboxypeptidase a2 (lci-cpa2)
|
|
X-ray(1.65Å)
|
|
12-Jul-00
|
|
|
|
×0
|
|
Nonstandard peptide binding of hla-b 5101 Complexed with HIV immunodominant epitope km1(lppvvakei)
|
|
X-ray(2.2Å)
|
|
12-Sep-00
|
|
|
|
×0
|
|
Crossreactive binding of a circularized peptide to an anti-tgfalpha antibody fab-fragment
|
|
X-ray(1.95Å)
|
|
12-Jul-01
|
|
|
|
×0
|
|
Complex structure of human thrombin with n-methyl-arginine inhibitor
|
|
X-ray(1.8Å)
|
|
28-Jan-02
|
|
|
|
×0
|
|
Crystal structure of protein tyrosine phosphatase 1b complexed with acetyl-e-l-e-f-ptyr-m-d-y-e-nh2
|
|
X-ray(1.8Å)
|
|
01-Feb-01
|
|
|
|
×0
|
|
Crystal structure of the tpr2a domain of hop in complex with the hsp90 peptide meevd
|
|
X-ray(1.9Å)
|
|
26-Apr-00
|
|
|
|
×2
|
|
Crystal structure of the tpr1 domain of hop in complex with a hsc70 peptide
|
|
X-ray(1.6Å)
|
|
26-Apr-00
|
|
|
|
×0
|
|
A structural comparison of 21 inhibitor complexes of the aspartic proteinase from endothia parasitica
|
|
X-ray(2Å)
|
|
20-Dec-94
|
|
|
|
×0
|
|
A structural comparison of 21 inhibitor complexes of the aspartic proteinase from endothia parasitica
|
|
X-ray(1.6Å)
|
|
20-Dec-94
|
|
|
|
×1
|
|
Crystal structure of metabotropic glutamate receptor subtype 1 complexed with glutamate
|
|
X-ray(2.2Å)
|
|
18-Dec-00
|
|
|
|
×1
|
|
Crystal structure of caspase-7 in complex with acetyl-asp-glu-val-asp- cho
|
|
X-ray(2.35Å)
|
|
23-May-01
|
|
|
|
×0
|
|
How does a symmetric dimer recognize an asymmetric substrate? a substrate complex of HIV-1 protease.
|
|
X-ray(2Å)
|
|
27-Jun-01
|
|
|
|
×0
|
|
Fab fragment of monoclonal antibody (lnkb-2) against human interleukin-2 in complex with antigenic peptide
|
|
X-ray(2.6Å)
|
|
11-Jul-01
|
|
|
|
×5
|
|
Caspase-8 specificity probed at subsite s4: crystal structure of the caspase-8-z-devd-cho
|
|
X-ray(2.9Å)
|
|
10-Jul-01
|
|
|
|
×0
|
|
Structure of a cbl-ubch7 complex: ring domain function in ubiquitin- protein ligases
|
|
X-ray(2.9Å)
|
|
30-Aug-00
|
|
|
|
×0
|
|
Solution structure of the fha2 domain of rad53 complexed with a phosphotyrosyl peptide
|
|
NMR(20 models)
|
|
18-Oct-00
|
|
|
|
×0
|
|
Structure of an inhibitor complex of proteinase from feline immunodeficiency virus
|
|
X-ray(2Å)
|
|
31-Jul-95
|
|
|
|
×2
|
|
Structure of beta-secretase complexed with inhibitor
|
|
X-ray(1.9Å)
|
|
09-Oct-00
|
|
|
|
×0
|
|
The 2.1 angstrom resolution crystal structure of the heterodimer of the human rxralpha and ppargamma ligand binding domains respectively bound with 9-cis retinoic acid and rosiglitazone and co-activator peptides.
|
|
X-ray(2.1Å)
|
|
16-Feb-01
|
|
|
|
×0
|
|
The 2.1 angstrom resolution crystal structure of the heterodimer of the human rxralpha and ppargamma ligand binding domains respectively bound with 9-cis retinoic acid and gi262570 and co-activator peptides.
|
|
X-ray(2.1Å)
|
|
16-Feb-01
|
|
|
|
×0
|
|
Structure of cyclic peptide inhibitors of mammalian ribonucleotide reductase
|
|
NMR(3 models)
|
|
22-Nov-00
|
|
|
|
×0
|
|
Active site mimetic inhibition of thrombin
|
|
X-ray(2.3Å)
|
|
27-Feb-95
|
|
|
|
×0
|
|
Crystal structure of the complex formed between the catalytic domain of shp-1 and an in vitro peptide substrate py469 derived from shps-1.
|
|
X-ray(2.5Å)
|
|
07-Mar-01
|
|
|
|
×2
|
|
Crystal structure of the glur2 ligand binding core (s1s2j) in complex with glutamate at 1.9 resolution
|
|
X-ray(1.9Å)
|
|
01-Nov-00
|
|
|
|
×0
|
|
Crystal structure of protein tyrosine phosphatase 1b complexed with a tri-phosphorylated peptide (rdi(ptr)etd(ptr)(ptr)rk) from the insulin receptor kinase
|
|
X-ray(2Å)
|
|
17-Jan-01
|
|
|
|
×0
|
|
Thrombin inhibitor complex
|
|
X-ray(2Å)
|
|
23-Oct-01
|
|
|
|
×0
|
|
Thrombin inhibitor complex
|
|
X-ray(1.9Å)
|
|
23-Oct-01
|
|
|
|
×0
|
|
Crystal structure of human alpha-thrombin complexed with bch-10556 and exosite-directed peptide
|
|
X-ray(2Å)
|
|
21-Apr-01
|
|
|
|
×0
|
|
Nmr structure of a 9 residue peptide from smac/diablo complexed to the bir3 domain of xiap
|
|
NMR(1 model)
|
|
10-Jan-01
|
|
|
|
×0
|
|
X-ray structure of the n-terminal fha domain from s. Cerevisiae rad53p in complex with a phosphothreonine peptide at 1.6 a resolution
|
|
X-ray(1.6Å)
|
|
13-Dec-00
|
|
|
|
×1
|
|
Crystal structure of pyrococcus protein a-1 e-form
|
|
X-ray(1.8Å)
|
|
23-Sep-01
|
|
|
|
×3
|
|
Glutaminase domain of glucosamine 6-phosphate synthase complexed with glutamate
|
|
X-ray(1.8Å)
|
|
14-Oct-96
|
|
|
|
×0
|
|
Glutamyl-tRNA reductase from methanopyrus kandleri
|
|
X-ray(1.95Å)
|
|
04-Jan-02
|
|
|
|
×0
|
|
Rb pocket bound to e7 lxcxe motif
|
|
X-ray(1.85Å)
|
|
02-Dec-98
|
|
|
|
×0
|
|
Endothiapepsin complexed with h256
|
|
X-ray(1Å)
|
|
04-Jul-02
|
|
|
|
×0
|
|
Cdk2/cyclina in complex with a 9 residue recruitment peptide from e2f
|
|
X-ray(2.5Å)
|
|
01-Feb-03
|
|
|
|
×1
|
|
Cdk2/cyclina in complex with an 11-residue recruitment peptide from p107
|
|
X-ray(2.8Å)
|
|
01-Feb-03
|
|
|
|
×0
|
|
Crystal structure of a heat- and protease-stable fragment of the bacteriophage t4 short fibre
|
|
X-ray(1.9Å)
|
|
13-Dec-01
|
|
