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PDBsum entry 7k0c
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Immune system
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PDB id
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7k0c
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Contents |
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534 a.a.
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(+ 4 more)
227 a.a.
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104 a.a.
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References listed in PDB file
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Key reference
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Title
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Structure of the human secretory immunoglobulin m core.
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Authors
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N.Kumar,
C.P.Arthur,
C.Ciferri,
M.L.Matsumoto.
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Ref.
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Structure, 2021,
29,
564.
[DOI no: ]
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PubMed id
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Abstract
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Immunoglobulins (Ig) A and M are the only human antibodies that form oligomers
and undergo transcytosis to mucosal secretions via the polymeric Ig receptor
(pIgR). When complexed with the J-chain (JC) and the secretory component (SC) of
pIgR, secretory IgA and IgM (sIgA and sIgM) play critical roles in host-pathogen
defense. Recently, we determined the structure of sIgA-Fc which elucidated the
mechanism of polymeric IgA assembly and revealed an extensive binding interface
between IgA-Fc, JC, and SC. Despite low sequence identity shared with IgA-Fc,
IgM-Fc also undergoes JC-mediated assembly and binds pIgR. Here, we report the
structure of sIgM-Fc and carryout a systematic comparison to sIgA-Fc. Our
structural analysis reveals a remarkably conserved mechanism of JC-templated
oligomerization and SC recognition of both IgM and IgA through a highly
conserved network of interactions. These studies reveal the structurally
conserved features of sIgM and sIgA required for function in mucosal immunity.
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