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PDBsum entry 6tut
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Transcription
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PDB id
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6tut
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Contents |
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1390 a.a.
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1097 a.a.
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334 a.a.
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104 a.a.
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215 a.a.
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83 a.a.
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199 a.a.
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146 a.a.
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43 a.a.
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67 a.a.
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102 a.a.
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45 a.a.
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166 a.a.
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125 a.a.
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551 a.a.
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196 a.a.
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79 a.a.
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142 a.a.
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References listed in PDB file
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Key reference
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Title
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Structural basis for RNA polymerase III transcription repression by maf1.
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Authors
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M.K.Vorländer,
F.Baudin,
R.D.Moir,
R.Wetzel,
W.J.H.Hagen,
I.M.Willis,
C.W.Müller.
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Ref.
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Nat Struct Mol Biol, 2020,
27,
229-232.
[DOI no: ]
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PubMed id
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Note: In the PDB file this reference is
annotated as "TO BE PUBLISHED". The citation details given above have
been manually determined.
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Abstract
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Maf1 is a conserved inhibitor of RNA polymerase III (Pol III) that influences
phenotypes ranging from metabolic efficiency to lifespan. Here, we present a
3.3-Å-resolution cryo-EM structure of yeast Maf1 bound to Pol III, establishing
that Maf1 sequesters Pol III elements involved in transcription initiation and
binds the mobile C34 winged helix 2 domain, sealing off the active site. The
Maf1 binding site overlaps with that of TFIIIB in the preinitiation complex.
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