UniProt functional annotation for P40992



	UniProt functional annotation for P40992

UniProt code: P40992.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Component of RNA polymerase I core factor complex (CF) that acts as a SUA7/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP- dependent manner to form a pre-initiation complex. {ECO:0000269|PubMed:21921198, ECO:0000269|PubMed:21940764, ECO:0000269|PubMed:8887672}.

Subunit: Component of the core factor (CF) complex, which consists of RRN6, RRN7 and RRN11. The CF heterotrimer may further dimerize to form a hexamer. RRN7 interacts with RRN6, RRN11, SPT15 and RRN9. {ECO:0000269|PubMed:7958901, ECO:0000269|PubMed:8702872, ECO:0000269|PubMed:8895657}.

Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.

Domain: Although it shares weak sequence similarity with SUA7/TFIIB, displays a similar subdomain organization as SUA7/TFIIB, with a N- terminal zinc finger, a connecting region (composed of B-reader and B- linker regions), followed by 2 cyclin folds. {ECO:0000269|PubMed:21921198}.

Miscellaneous: Present with 398 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Similarity: Belongs to the RRN7/TAF1B family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Component of RNA polymerase I core factor complex (CF) that acts as a SUA7/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP- dependent manner to form a pre-initiation complex. {ECO:0000269\|PubMed:21921198, ECO:0000269\|PubMed:21940764, ECO:0000269\|PubMed:8887672}.


Subunit:		Component of the core factor (CF) complex, which consists of RRN6, RRN7 and RRN11. The CF heterotrimer may further dimerize to form a hexamer. RRN7 interacts with RRN6, RRN11, SPT15 and RRN9. {ECO:0000269\|PubMed:7958901, ECO:0000269\|PubMed:8702872, ECO:0000269\|PubMed:8895657}.
Subcellular location:		Nucleus, nucleolus {ECO:0000269\|PubMed:14562095}.
Domain:		Although it shares weak sequence similarity with SUA7/TFIIB, displays a similar subdomain organization as SUA7/TFIIB, with a N- terminal zinc finger, a connecting region (composed of B-reader and B- linker regions), followed by 2 cyclin folds. {ECO:0000269\|PubMed:21921198}.
Miscellaneous:		Present with 398 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity:		Belongs to the RRN7/TAF1B family. {ECO:0000305}.