UniProt functional annotation for Q969H8



	UniProt functional annotation for Q969H8

UniProt code: Q969H8.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518). {ECO:0000250|UniProtKB:Q9CPT4, ECO:0000269|PubMed:25581518}.

Subcellular location: Secreted {ECO:0000269|PubMed:17362502, ECO:0000269|PubMed:25581518}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:17362502}. Endoplasmic reticulum {ECO:0000269|PubMed:29954947}. Golgi apparatus {ECO:0000269|PubMed:29954947}. Note=The C-terminal RTEL motif may provide retention in the endoplasmic reticulum. {ECO:0000269|PubMed:25581518, ECO:0000269|PubMed:29954947}.

Tissue specificity: Expressed in eosinophils (at protein level) (PubMed:29954947). Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502). {ECO:0000269|PubMed:17362502, ECO:0000269|PubMed:25581518, ECO:0000269|PubMed:29954947}.

Induction: Up-regulated in response to myocardial infarction (MI). {ECO:0000269|PubMed:25581518}.

Similarity: Belongs to the MYDGF family. {ECO:0000305}.

Sequence caution: Sequence=AAC27824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC33800.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518). {ECO:0000250\|UniProtKB:Q9CPT4, ECO:0000269\|PubMed:25581518}.


Subcellular location:		Secreted {ECO:0000269\|PubMed:17362502, ECO:0000269\|PubMed:25581518}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269\|PubMed:17362502}. Endoplasmic reticulum {ECO:0000269\|PubMed:29954947}. Golgi apparatus {ECO:0000269\|PubMed:29954947}. Note=The C-terminal RTEL motif may provide retention in the endoplasmic reticulum. {ECO:0000269\|PubMed:25581518, ECO:0000269\|PubMed:29954947}.
Tissue specificity:		Expressed in eosinophils (at protein level) (PubMed:29954947). Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502). {ECO:0000269\|PubMed:17362502, ECO:0000269\|PubMed:25581518, ECO:0000269\|PubMed:29954947}.
Induction:		Up-regulated in response to myocardial infarction (MI). {ECO:0000269\|PubMed:25581518}.
Similarity:		Belongs to the MYDGF family. {ECO:0000305}.
Sequence caution:		Sequence=AAC27824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC33800.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};