|
|
||
|
|
|
|
|
UniProt functional annotation for Q96BY9 | ||
|
|
|
|
|
|
||
| UniProt code: Q96BY9. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. {ECO:0000269|PubMed:22464749}. |
|
||
| Subunit: | |
Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB. {ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:30481768}. |
| Subcellular location: | |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:22464749}; Single-pass type I membrane protein {ECO:0000269|PubMed:22464749}. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation. |
| Subcellular location: | |
[Isoform 2]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
| Tissue specificity: | |
Highly expressed in macrophages. {ECO:0000269|Ref.2}. |
| Domain: | |
The cytoplasmic C-terminal region mediates interaction with STIM1, while the N-terminal lumenal region mediates regulation of SOCE activity. {ECO:0000269|PubMed:22464749}. |
| Similarity: | |
Belongs to the SARAF family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAD44487.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.