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UniProt functional annotation for Q9QXC1 | ||
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| UniProt code: Q9QXC1. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening. {ECO:0000269|PubMed:23562279}. |
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| Subcellular location: | |
Secreted {ECO:0000305|PubMed:23562279}. |
| Tissue specificity: | |
Liver, lung and tongue. |
| Disruption phenotype: | |
Female infertility due to a block early in fertilization. Oocytes undergo premature zona pellucida hardening. {ECO:0000269|PubMed:23562279}. |
| Similarity: | |
Belongs to the fetuin family. {ECO:0000255|PROSITE- ProRule:PRU00862}. |
Annotations taken from UniProtKB at the EBI.