UniProt functional annotation for O29760



	UniProt functional annotation for O29760

UniProt code: O29760.

Organism: Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126).

Taxonomy: Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae; Archaeoglobus.

Function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. {ECO:0000255|HAMAP-Rule:MF_00289}.

Activity regulation: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close- gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. {ECO:0000255|HAMAP-Rule:MF_00289}.

Subunit: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has probably a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha- subunits. Is likely capped at one or both ends by the proteasome regulatory ATPase, PAN. {ECO:0000269|PubMed:12614609}.

Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00289}.

Similarity: Belongs to the peptidase T1A family. {ECO:0000255|HAMAP- Rule:MF_00289}.

Annotations taken from UniProtKB at the EBI.


Organism:		Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126).
Taxonomy:		Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae; Archaeoglobus.



Function:		Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. {ECO:0000255\|HAMAP-Rule:MF_00289}.


Activity regulation:		The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close- gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. {ECO:0000255\|HAMAP-Rule:MF_00289}.
Subunit:		The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has probably a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha- subunits. Is likely capped at one or both ends by the proteasome regulatory ATPase, PAN. {ECO:0000269\|PubMed:12614609}.
Subcellular location:		Cytoplasm {ECO:0000255\|HAMAP-Rule:MF_00289}.
Similarity:		Belongs to the peptidase T1A family. {ECO:0000255\|HAMAP- Rule:MF_00289}.