PDBsum entry 6glg

Hydrolase

PDB id: 6glg

Contents

Protein chain

155 a.a.

Ligands

BU8

SO4

ACT

Waters ×183

PDB id:

6glg

Name:

Hydrolase

Title:

Crystal structure of hmth1 f27a in complex with lw14 in the presence of acetate

Structure:

7,8-dihydro-8-oxoguanine triphosphatase. Chain: a. Synonym: 2-hydroxy-datp diphosphatase,8-oxo-dgtpase,nucleoside diphosphate-linked moiety x motif 1,nudix motif 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: nudt1, mth1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

1.31Å R-factor: 0.194 R-free: 0.211

Authors:

S.A.Eberle,L.Wiedmer,P.Sledz,A.Caflisch

Key ref:

S.A.Eberle et al. Hmth1 f27a in complex with lw14. To be published, .

Date:

23-May-18 Release date: 20-Feb-19

Protein chain

P36639  (8ODP_HUMAN) -  Oxidized purine nucleoside triphosphate hydrolase from Homo sapiens

Seq: 156 a.a.

Struc: 155 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 2: E.C.3.6.1.- - ?????
• Enzyme class 3: E.C.3.6.1.56 - 2-hydroxy-dATP diphosphatase.
• Reaction: 2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site