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UniProt functional annotation for B0B9A0 | ||
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| UniProt code: B0B9A0. |
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| Organism: | |
Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B). |
| Taxonomy: | |
Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydia/Chlamydophila group; Chlamydia. |
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| Function: | |
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease possesses deubiquitinating and deneddylating activities (By similarity). Impairs ubiquitination and degradation of NF-kappa-B inhibitor alpha (NFKBIA), thereby preventing NF-kappa-B activation. {ECO:0000250, ECO:0000269|PubMed:18503636}. |
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| Subunit: | |
Binds to host NFKBIA. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:18503636}. Host cell {ECO:0000269|PubMed:18503636}. Membrane {ECO:0000269|PubMed:18503636}; Single-pass membrane protein {ECO:0000269|PubMed:18503636}. Note=Secreted, and delivered into the host cell. Located predominantly on the plasma membrane and to a lesser extent on intracellular membranes, especially the host cell nuclear envelope. |
| Induction: | |
Expressed late in the infectious cycle. {ECO:0000269|PubMed:18503636}. |
| Similarity: | |
Belongs to the peptidase C48 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.