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UniProt functional annotation for P21401 | ||
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| UniProt code: P21401. |
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| Organism: | |
Rift valley fever virus (strain ZH-548 M12) (RVFV). |
| Taxonomy: | |
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Ellioviricetes; Bunyavirales; Phenuiviridae; Phlebovirus. |
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| Function: | |
[Glycoprotein N]: Structural component of the virion that interacts with glycoprotein N. About 720 Gn and 720 Gc proteins form 12 pentameric and 110 hexameric capsomeres. Theses capsomeres are arranged on the virus envelop surface in an icosahedral lattice with a T=12 quasisymmetry. Attaches the virion to a cell receptor and thereby promotes fusion after endocytosis of the virion. Contains a Golgi retention signal on its C-terminal region and brings Gc to the host Golgi apparatus where assembly occurs. {ECO:0000269|PubMed:18715915, ECO:0000269|PubMed:21445316}. |
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| Function: | |
[Glycoprotein C]: Structural component of the virion that interacts with glycoprotein C. About 720 Gn and 720 Gc proteins form 12 pentameric and 110 hexameric capsomeres. Theses capsomeres are arranged on the virus envelop surface in an icosahedral lattice with a T=12 quasisymmetry. Attaches the virion to a cell receptor and thereby promotes fusion after endocytosis of the virion. {ECO:0000269|PubMed:18715915}. |
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| Function: | |
[Isoform NSm protein]: Plays a role in the inhibition of virus-induced apoptosis. Plays a role for virus dissemination in vertebrates. {ECO:0000269|PubMed:23097454, ECO:0000269|PubMed:26038497}. |
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| Function: | |
[NSm-Gn protein]: Plays a role for virus dissemination in mosquitoes. May act as a structural virion protein in insects. {ECO:0000269|PubMed:24489907, ECO:0000269|PubMed:26038497}. |
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| Subunit: | |
Glycoprotein C and Glycoprotein N interact with each other. Glycoprotein Gn interacts with nucleocapsid protein N and with the polymerase L in order to package them into virus particles. {ECO:0000269|PubMed:21445316}. |
| Subcellular location: | |
[Glycoprotein N]: Virion membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Host Golgi apparatus membrane {ECO:0000269|PubMed:12414959, ECO:0000269|PubMed:21445316}; Single-pass type I membrane protein {ECO:0000305}. Host endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Subcellular location: | |
[Glycoprotein C]: Virion membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Host Golgi apparatus membrane {ECO:0000269|PubMed:12414959}; Single-pass type I membrane protein {ECO:0000305}. Note=Interaction between Gn and Gc is essential for proper targeting of GC to the Golgi complex, where virion budding occurs. {ECO:0000269|PubMed:12414959}. |
| Subcellular location: | |
[Isoform NSm protein]: Host mitochondrion outer membrane {ECO:0000269|PubMed:23097454}. |
| Subcellular location: | |
[NSm-Gn protein]: Host Golgi apparatus {ECO:0000269|PubMed:3046119}. Virion {ECO:0000269|PubMed:24489907}. Note=Localizes in virions maturing in cells of insect origin but not in cells of mammalian origin. {ECO:0000269|PubMed:24489907}. |
| Ptm: | |
[Envelopment polyprotein]: Specific enzymatic cleavages in vivo yield mature proteins including NSm protein, Glycoprotein C, and Glycoprotein N. {ECO:0000269|PubMed:16963099}. |
| Ptm: | |
[Glycoprotein C]: Glycosylated by host (PubMed:2728348). The glycans can attach to host CD209/DC-SIGN, and may play a role in virus entry into dendritic cells (PubMed:21767814). {ECO:0000269|PubMed:21767814, ECO:0000269|PubMed:2728348}. |
| Ptm: | |
[Glycoprotein N]: Glycosylated by host (PubMed:2728348). The glycans can attach to host CD209/DC-SIGN, and may play a role in virus entry into dendritic cells (PubMed:21767814). {ECO:0000269|PubMed:21767814, ECO:0000269|PubMed:2728348}. |
| Similarity: | |
Belongs to the phlebovirus envelope glycoprotein family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.