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UniProt functional annotation for Q9X1X7 | ||
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| UniProt code: Q9X1X7. |
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| Organism: | |
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8). |
| Taxonomy: | |
Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga. |
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| Function: | |
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. {ECO:0000255|HAMAP- Rule:MF_00568}. |
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| Catalytic activity: | |
Reaction=dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate; Xref=Rhea:RHEA:25888, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29959, ChEBI:CHEBI:43474, ChEBI:CHEBI:57642, ChEBI:CHEBI:77875; EC=2.5.1.72; Evidence={ECO:0000255|HAMAP-Rule:MF_00568}; |
| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000255|HAMAP-Rule:MF_00568}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO:0000255|HAMAP- Rule:MF_00568}; |
| Pathway: | |
Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00568}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00568}. |
| Similarity: | |
Belongs to the quinolinate synthase A family. Type 2 subfamily. {ECO:0000255|HAMAP-Rule:MF_00568}. |
Annotations taken from UniProtKB at the EBI.