PDBsum entry 6f3c

DNA

PDB id: 6f3c

Contents

DNA/RNA

Ligands

PT9-PT9

Metals

_MG

Waters ×9

References listed in PDB file

Key reference

• Title: Induction of a four-Way junction structure in the DNA palindromic hexanucleotide 5'-D(cgtacg)-3' By a mononuclear platinum complex.
• Authors: V.H.S.Van rixel, A.Busemann, M.F.Wissingh, S.L.Hopkins, B.Siewert, C.Van de griend, M.A.Siegler, T.Marzo, F.Papi, M.Ferraroni, P.Gratteri, C.Bazzicalupi, L.Messori, S.Bonnet.
• Ref.: Angew Chem Int Ed Engl, 2019, 58, 9378-9382. [DOI no: 10.1002/anie.201814532]
• PubMed id: 31046177

Abstract

Four-way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA-damage repair. In this study, a new mononuclear platinum(II) complex 1 was prepared that is capable of driving the crystallization of the DNA oligomer 5'-d(CGTACG)-3' specifically into a 4WJ-like motif. In the crystal structure of the 1-CGTACG adduct, the distorted-square-planar platinum complex binds to the core of the 4WJ-like motif through π-π stacking and hydrogen bonding, without forming any platinum-nitrogen coordination bonds. Our observations suggest that the specific molecular properties of the metal complex are crucially responsible for triggering the selective assembly of this peculiar DNA superstructure.