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PDBsum entry 6e4x
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Viral protein/immune system
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PDB id
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6e4x
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Contents |
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275 a.a.
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208 a.a.
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231 a.a.
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References listed in PDB file
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Key reference
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Title
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Antibodies to a conserved influenza head interface epitope protect by an igg subtype-Dependent mechanism.
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Authors
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A.Watanabe,
K.R.Mccarthy,
M.Kuraoka,
A.G.Schmidt,
Y.Adachi,
T.Onodera,
K.Tonouchi,
T.M.Caradonna,
G.Bajic,
S.Song,
C.E.Mcgee,
G.D.Sempowski,
F.Feng,
P.Urick,
T.B.Kepler,
Y.Takahashi,
S.C.Harrison,
G.Kelsoe.
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Ref.
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Cell, 2019,
177,
1124.
[DOI no: ]
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PubMed id
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Abstract
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Vaccines to generate durable humoral immunity against antigenically evolving
pathogens such as the influenza virus must elicit antibodies that recognize
conserved epitopes. Analysis of single memory B cells from immunized human
donors has led us to characterize a previously unrecognized epitope of influenza
hemagglutinin (HA) that is immunogenic in humans and conserved among influenza
subtypes. Structures show that an unrelated antibody from a participant in an
experimental infection protocol recognized the epitope as well. IgGs specific
for this antigenic determinant do not block viral infection in vitro, but
passive administration to mice affords robust IgG subtype-dependent protection
against influenza infection. The epitope, occluded in the pre-fusion form of HA,
is at the contact surface between HA head domains; reversible molecular
"breathing" of the HA trimer can expose the interface to antibody and
B cells. Antigens that present this broadly immunogenic HA epitope may be good
candidates for inclusion in "universal" flu vaccines.
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