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UniProt functional annotation for O95639 | ||
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| UniProt code: O95639. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:9224719}. |
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| Subunit: | |
Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with FIP1L1. {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:21102410}. |
| Subunit: | |
(Microbial infection) Interacts with influenza A virus NS1 blocks processing of pre-mRNAs, thereby preventing nuclear export of host cell mRNAs. {ECO:0000269|PubMed:9651582}. |
| Subcellular location: | |
Nucleus. |
| Miscellaneous: | |
[Isoform 3]: May be due to a competing acceptor splice site. {ECO:0000305}. |
| Similarity: | |
Belongs to the CPSF4/YTH1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.