PDBsum entry 6csc

Oxo-acid-lyase

PDB id: 6csc

Contents

Protein chains

437 a.a. *

Ligands

COF ×2

CIT ×2

Waters ×146

* Residue conservation analysis

References listed in PDB file

Key reference

Title

Trifluoroacetonyl coenzyme a, An inhibitor of citrate synthase, Binds in a combination of productive and nonproductive modes

Authors

K.C.Usher, B.Branchaud, S.J.Remington.

Ref.

To be Published ...

Secondary reference #1

Title

A very short hydrogen bond provides only moderate stabilization of an enzyme-Inhibitor complex of citrate synthase.

Authors

K.C.Usher, S.J.Remington, D.P.Martin, D.G.Drueckhammer.

Ref.

Biochemistry, 1994, 33, 7753-7759. [DOI no: 10.1021/bi00191a002]

PubMed id

8011640

Secondary reference #2

Title

Crystal structure analysis and molecular model of a complex of citrate synthase with oxaloacetate and s-Acetonyl-Coenzyme a.

Authors

G.Wiegand, S.Remington, J.Deisenhofer, R.Huber.

Ref.

J Mol Biol, 1984, 174, 205-219. [DOI no: 10.1016/0022-2836(84)90373-5]

PubMed id

6716477

Figure 2.
FIG. 2. The small omains of the closed form (C2) and the closed form (P4,2,2) are optimally superimposed and shown in the stereo diagram. The conformations also differ substantially for internal residues as ndicated specifically for some residues.

The above figure is reproduced from the cited reference with permission from Elsevier

Secondary reference #3

Title

Crystallographic refinement and atomic models of two different forms of citrate synthase at 2.7 and 1.7 a resolution.

Authors

S.Remington, G.Wiegand, R.Huber.

Ref.

J Mol Biol, 1982, 158, 111-152. [DOI no: 10.1016/0022-2836(82)90452-1]

PubMed id

7120407

Figure 1.
BVIE

Figure 19.
FIG. 19. Stereo drawing of the citryl-thioether-CoA analogue ((XC%NPH6) difference Fourier map superimposed on the monoclinic model. Contours are at +49 e. with negative contours dashed. The Figure is discussd in the text.

The above figures are reproduced from the cited reference with permission from Elsevier