UniProt functional annotation for Q8N423



	UniProt functional annotation for Q8N423

UniProt code: Q8N423.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042). Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885). {ECO:0000269|PubMed:11169396, ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:12853576, ECO:0000269|PubMed:16455647, ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:27859042, ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.

Subunit: Binds PTPN6 when phosphorylated. Binds FCGR1A. Interacts with peptide-bound HLA-G-B2M; this interaction is direct (PubMed:16455647). Interacts with peptide-bound HLA-F-B2M; this interaction is direct (PubMed:11169396). {ECO:0000269|PubMed:11169396, ECO:0000269|PubMed:16455647}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:20448110}; Single-pass type I membrane protein.

Tissue specificity: Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells (PubMed:20448110). Expressed in myeloid- derived suppressor cells during pregnancy (PubMed:27859042). Detected at low levels in natural killer (NK) cells. Expressed in B cells. {ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:27859042, ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.

Domain: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Ptm: Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. {ECO:0000269|PubMed:9842885}.

Miscellaneous: [Isoform 2]: Alternative use of an acceptor site. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042). Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885). {ECO:0000269\|PubMed:11169396, ECO:0000269\|PubMed:11875462, ECO:0000269\|PubMed:12853576, ECO:0000269\|PubMed:16455647, ECO:0000269\|PubMed:20448110, ECO:0000269\|PubMed:27859042, ECO:0000269\|PubMed:9548455, ECO:0000269\|PubMed:9842885}.


Subunit:		Binds PTPN6 when phosphorylated. Binds FCGR1A. Interacts with peptide-bound HLA-G-B2M; this interaction is direct (PubMed:16455647). Interacts with peptide-bound HLA-F-B2M; this interaction is direct (PubMed:11169396). {ECO:0000269\|PubMed:11169396, ECO:0000269\|PubMed:16455647}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:20448110}; Single-pass type I membrane protein.
Tissue specificity:		Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells (PubMed:20448110). Expressed in myeloid- derived suppressor cells during pregnancy (PubMed:27859042). Detected at low levels in natural killer (NK) cells. Expressed in B cells. {ECO:0000269\|PubMed:20448110, ECO:0000269\|PubMed:27859042, ECO:0000269\|PubMed:9548455, ECO:0000269\|PubMed:9842885}.
Domain:		Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Ptm:		Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. {ECO:0000269\|PubMed:9842885}.
Miscellaneous:		[Isoform 2]: Alternative use of an acceptor site. {ECO:0000305}.