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PDBsum entry 5us1

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protein ligands Protein-protein interface(s) links
Transferase PDB id
5us1
Jmol PyMol
Contents
Protein chains
189 a.a.
(+ 5 more) 178 a.a.
Ligands
8MM ×10
TAR ×5
ACO
GOL ×3
COA ×3
Waters ×581
PDB id:
5us1
Name: Transferase
Title: Crystal structure of aminoglycoside acetyltransferase aac(2' complex with n2'-acetylgentamicin c1a and coenzyme a
Structure: Aminoglycoside 2'-n-acetyltransferase. Chain: a, b, c, d, e, f, g, h, i, j, k, l. Synonym: aac(2')-ia. Engineered: yes
Source: Providencia stuartii. Organism_taxid: 588. Gene: aac. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.48Å     R-factor:   0.189     R-free:   0.230
Authors: P.J.Stogios,E.Evdokimova,Z.Xu,Z.Wawrzak,A.Savchenko,W.F.Ande Center For Structural Genomics Of Infectious Diseases (Csgi
Key ref: P.J.Stogios Crystal structure of aminoglycoside acetyltransferase aac(2')-Ia in complex with n2'-Acetylgentamicin c1a a coenzyme a. To be published, .
Date:
13-Feb-17     Release date:   15-Mar-17    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q52424  (AAC2_PROST) -  Aminoglycoside 2'-N-acetyltransferase
Seq:
Struc:
178 a.a.
189 a.a.
Protein chains
Pfam   ArchSchema ?
Q52424  (AAC2_PROST) -  Aminoglycoside 2'-N-acetyltransferase
Seq:
Struc:
178 a.a.
178 a.a.
Key:    PfamA domain  Secondary structure

 Enzyme reactions 
   Enzyme class: Chains A, B, C, D, E, F, G, H, I, J, K, L: E.C.2.3.1.59  - Gentamicin 2'-N-acetyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Acetyl-CoA + gentamicin C(1a) = CoA + N(2')-acetylgentamicin C(1a)
Acetyl-CoA
Bound ligand (Het Group name = ACO)
corresponds exactly
+
gentamicin C(1a)
Bound ligand (Het Group name = 8MM)
matches with 91.18% similarity
= CoA
+ N(2')-acetylgentamicin C(1a)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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