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PDBsum entry 5urq

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protein ligands metals Protein-protein interface(s) links
Oxidoreductase/oxidoreductase inhibitor PDB id
5urq
Jmol PyMol
Contents
Protein chains
(+ 2 more) 355 a.a.
Ligands
IMP ×8
8L7 ×8
Metals
__K ×8
Waters ×17
PDB id:
5urq
Name: Oxidoreductase/oxidoreductase inhibitor
Title: Crystal structure of the catalytic domain of the inosine mon dehydrogenase from campylobacter jejuni in the complex with p176
Structure: Inosine-5'-monophosphate dehydrogenase. Chain: a, b, c, d, e, f, h, g. Synonym: impdh. Engineered: yes
Source: Campylobacter jejuni subsp. Jejuni, campylobacter jejuni subsp. Jejuni cg8486. Organism_taxid: 32022, 398000. Gene: guab, cj14980a_1064, guab, cj8486_1016. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.70Å     R-factor:   0.183     R-free:   0.235
Authors: Y.Kim,N.Maltseva,M.Makowska-Grzyska,M.Gu,D.Gollapalli,L.Heds W.F.Anderson,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid)
Key ref: Y.Kim et al. Crystal structure of the catalytic domain of the inos monophosphate dehydrogenase from campylobacter jejuni complex with inhibitor p176. To be published, .
Date:
12-Feb-17     Release date:   01-Mar-17    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
A5KFK9  (A5KFK9_CAMJU) -  Inosine-5'-monophosphate dehydrogenase
Seq:
Struc:
445 a.a.
355 a.a.
Key:    PfamA domain  Secondary structure

 Enzyme reactions 
   Enzyme class: E.C.1.1.1.205  - Imp dehydrogenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
AMP and GMP Biosynthesis
      Reaction: Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH
Inosine 5'-phosphate
Bound ligand (Het Group name = IMP)
corresponds exactly
+ NAD(+)
+ H(2)O
= xanthosine 5'-phosphate
+ NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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