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PDBsum entry 5uqf

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protein ligands metals Protein-protein interface(s) links
Oxidoreductase/oxidoreductase inhibitor PDB id
5uqf
Jmol PyMol
Contents
Protein chains
354 a.a.
Ligands
IMP ×3
8KY ×3
SO4 ×10
EDO ×6
GOL ×2
Metals
_CL ×2
__K ×3
Waters ×70
PDB id:
5uqf
Name: Oxidoreductase/oxidoreductase inhibitor
Title: Crystal structure of the catalytic domain of the inosine mon dehydrogenase from campylobacter jejuni in the complex with the inhibitor p225
Structure: Inosine-5'-monophosphate dehydrogenase. Chain: a, b, c. Synonym: impdh. Engineered: yes. Mutation: yes
Source: Campylobacter jejuni subsp. Jejuni, campylobacter jejuni subsp. Jejuni cg8486. Organism_taxid: 32022, 398000. Gene: guab, cj14980a_1064, guab, cj8486_1016. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.73Å     R-factor:   0.177     R-free:   0.228
Authors: Y.Kim,N.Maltseva,M.Makowska-Grzyska,M.Gu,D.Gollapalli,L.Heds W.F.Anderson,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid)
Key ref: Y.Kim et al. Crystal structure of the catalytic domain of the inos monophosphate dehydrogenase from campylobacter jejuni complex with imp and the inhibitor p225. To be published, .
Date:
08-Feb-17     Release date:   01-Mar-17    
PROCHECK
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 Headers
 References

Protein chains
Pfam  
A0A1E7NPJ1  (A0A1E7NPJ1_CAMJU) - 
Key:    Secondary structure

 Enzyme reactions 
   Enzyme class: E.C.1.1.1.205  - Imp dehydrogenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
AMP and GMP Biosynthesis
      Reaction: Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH
Inosine 5'-phosphate
Bound ligand (Het Group name = IMP)
corresponds exactly
+ NAD(+)
+ H(2)O
= xanthosine 5'-phosphate
+ NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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