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PDBsum entry 5upv

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protein ligands links
Oxidoreductase/oxidoreductase inhibitor PDB id
5upv
Jmol PyMol
Contents
Protein chain
352 a.a.
Ligands
IMP
8KV
FMT ×3
EDO ×3
Waters ×159
PDB id:
5upv
Name: Oxidoreductase/oxidoreductase inhibitor
Title: Crystal structure of the catalytic domain of the inosine mon dehydrogenase from mycobacterium tuberculosis in the presen
Structure: Inosine-5'-monophosphate dehydrogenase. Chain: a. Synonym: impdh,impdh2. Engineered: yes. Mutation: yes
Source: Mycobacterium tuberculosis (strain atc h37rv). Organism_taxid: 83332. Strain: atcc 25618 / h37rv. Gene: guab, guab2, rv3411c, mtcy78.17. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
1.63Å     R-factor:   0.164     R-free:   0.184
Authors: Y.Kim,N.Maltseva,R.Mulligan,M.Makowska-Grzyska,M.Gu,W.F.Ande A.Joachimiak,Center For Structural Genomics Of Infectious D (Csgid)
Key ref: Y.Kim et al. Crystal structure of the catalytic domain of the inos monophosphate dehydrogenase from mycobacterium tuberc in the presence of g36. To be published, .
Date:
04-Feb-17     Release date:   22-Feb-17    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam  
P9WKI7  (IMDH_MYCTU) -  Inosine-5'-monophosphate dehydrogenase
Seq:
Struc:
 
Seq:
Struc:
529 a.a.
352 a.a.*
Key:    Secondary structure
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.1.1.1.205  - Imp dehydrogenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
AMP and GMP Biosynthesis
      Reaction: Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH
Inosine 5'-phosphate
Bound ligand (Het Group name = IMP)
corresponds exactly
+ NAD(+)
+ H(2)O
= xanthosine 5'-phosphate
+ NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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