PDBsum entry 5tpa

Transport protein

PDB id: 5tpa

Contents

Protein chains

275 a.a.

279 a.a.

Ligands

GLU

7H2

GLY

Waters ×147

PDB id:

5tpa

Name:

Transport protein

Title:

Structure of the human glun1/glun2a lbd in complex with compound 9 (gne3500)

Structure:

Glutamate receptor ionotropic, nmda 2a. Chain: a. Fragment: ligand binding domain (unp residues 401-539, gt linker, unp residues 661-802). Synonym: glun2a, glutamate [nmda] receptor subunit epsilon-1, n- methyl d-aspartate receptor subtype 2a, hnr2a. Engineered: yes. Glutamate receptor ionotropic, nmda 1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: grin2a, nmdar2a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: grin1, nmdar1. Expression_system_taxid: 7108

Resolution:

2.48Å R-factor: 0.190 R-free: 0.241

Authors:

H.J.A.Wallweber,P.J.Lupardus

Key ref:

E.Villemure et al. (2017). GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. Acs Med Chem Lett, 8, 84-89. PubMed id: 28105280 DOI: 10.1021/acsmedchemlett.6b00388

Date:

20-Oct-16 Release date: 30-Nov-16

Protein chain

Q12879  (NMDE1_HUMAN) -  Glutamate receptor ionotropic, NMDA 2A from Homo sapiens

Seq: 1464 a.a.

Struc: 275 a.a.

Protein chain

Q05586  (NMDZ1_HUMAN) -  Glutamate receptor ionotropic, NMDA 1 from Homo sapiens

Seq: 938 a.a.

Struc: 279 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

DOI no: 10.1021/acsmedchemlett.6b00388

Acs Med Chem Lett 8:84-89 (2017)

PubMed id: 28105280

GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.

E.Villemure, M.Volgraf, Y.Jiang, G.Wu, C.Q.Ly, P.W.Yuen, A.Lu, X.Luo, M.Liu, S.Zhang, P.J.Lupardus, H.J.Wallweber, B.M.Liederer, G.Deshmukh, E.Plise, S.Tay, T.M.Wang, J.E.Hanson, D.H.Hackos, K.Scearce-Levie, J.B.Schwarz, B.D.Sellers.

ABSTRACT

No abstract given.