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PDBsum entry 5tgo
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Viral protein
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PDB id
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5tgo
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References listed in PDB file
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Key reference
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Title
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The 150-Loop restricts the host specificity of human h10n8 influenza virus.
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Authors
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N.Tzarum,
R.P.De vries,
W.Peng,
A.J.Thompson,
K.M.Bouwman,
R.Mcbride,
W.Yu,
X.Zhu,
M.H.Verheije,
J.C.Paulson,
I.A.Wilson.
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Ref.
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Cell Rep, 2017,
19,
235-245.
[DOI no: ]
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PubMed id
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Abstract
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Adaptation of influenza A viruses to new hosts are rare events but are the
basis for emergence of new influenza pandemics in the human population. Thus,
understanding the processes involved in such events is critical for anticipating
potential pandemic threats. In 2013, the first case of human infection by an
avian H10N8 virus was reported, yet the H10 hemagglutinin (HA) maintains avian
receptor specificity. However, the 150-loop of H10 HA, as well as related H7 and
H15 subtypes, contains a two-residue insert that can potentially block human
receptor binding. Mutation of the 150-loop on the background of Q226L and G228S
mutations, which arose in the receptor-binding site of human pandemic H2 and H3
viruses, resulted in acquisition of human-type receptor specificity. Crystal
structures of H10 HA mutants with human and avian receptor analogs,
receptor-binding studies, and tissue staining experiments illustrate the
important role of the 150-loop in H10 receptor specificity.
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