PDBsum entry 5t0i

Hydrolase

PDB id: 5t0i

Contents

Protein chains

361 a.a.

348 a.a.

384 a.a.

380 a.a.

353 a.a.

366 a.a.

240 a.a.

233 a.a.

250 a.a.

239 a.a.

228 a.a.

238 a.a.

240 a.a.

191 a.a.

220 a.a.

204 a.a.

199 a.a.

201 a.a.

213 a.a.

215 a.a.

806 a.a.

480 a.a.

456 a.a.

241 a.a.

378 a.a.

286 a.a.

373 a.a.

191 a.a.

278 a.a.

257 a.a.

40 a.a.

694 a.a.

Ligands

ATP ×4

Metals

_ZN

PDB id:

5t0i

Name:

Hydrolase

Title:

Structural basis for dynamic regulation of the human 26s proteasome

Structure:

26s protease regulatory subunit 7. Chain: a. Synonym: 26s proteasome aaa-atpase subunit rpt1,proteasome 26s subunit atpase 2,protein mss1. 26s protease regulatory subunit 4. Chain: b. Synonym: p26s4,26s proteasome aaa-atpase subunit rpt2,proteasome 26s subunit atpase 1. 26s protease regulatory subunit 8.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606

Authors:

S.Chen,J.Wu,Y.Lu,Y.B.Ma,B.H.Lee,Z.Yu,Q.Ouyang,D.Finley,M.W.Kirschner, Y.Mao

Key ref:

S.Chen et al. (2016). Structural basis for dynamic regulation of the human 26S proteasome. Proc Natl Acad Sci U S A, 113, 12991-12996. PubMed id: 27791164 DOI: 10.1073/pnas.1614614113

Date:

16-Aug-16 Release date: 19-Oct-16

Protein chain

P35998  (PRS7_HUMAN) -  26S proteasome regulatory subunit 7 from Homo sapiens

Seq: 433 a.a.

Struc: 361 a.a.

Protein chain

P62191  (PRS4_HUMAN) -  26S proteasome regulatory subunit 4 from Homo sapiens

Seq: 440 a.a.

Struc: 348 a.a.

Protein chain

P62195  (PRS8_HUMAN) -  26S proteasome regulatory subunit 8 from Homo sapiens

Seq: 406 a.a.

Struc: 384 a.a.

Protein chain

P43686  (PRS6B_HUMAN) -  26S proteasome regulatory subunit 6B from Homo sapiens

Seq: 418 a.a.

Struc: 380 a.a.

Protein chain

P62333  (PRS10_HUMAN) -  26S proteasome regulatory subunit 10B from Homo sapiens

Seq: 389 a.a.

Struc: 353 a.a.

Protein chain

P17980  (PRS6A_HUMAN) -  26S proteasome regulatory subunit 6A from Homo sapiens

Seq: 439 a.a.

Struc: 366 a.a.

Protein chain

P60900  (PSA6_HUMAN) -  Proteasome subunit alpha type-6 from Homo sapiens

Seq: 246 a.a.

Struc: 240 a.a.

Protein chain

P25787  (PSA2_HUMAN) -  Proteasome subunit alpha type-2 from Homo sapiens

Seq: 234 a.a.

Struc: 233 a.a.

Protein chain

P25789  (PSA4_HUMAN) -  Proteasome subunit alpha type-4 from Homo sapiens

Seq: 261 a.a.

Struc: 250 a.a.

Protein chain

O14818  (PSA7_HUMAN) -  Proteasome subunit alpha type-7 from Homo sapiens

Seq: 248 a.a.

Struc: 239 a.a.

Protein chain

P28066  (PSA5_HUMAN) -  Proteasome subunit alpha type-5 from Homo sapiens

Seq: 241 a.a.

Struc: 228 a.a.

Protein chain

P25786  (PSA1_HUMAN) -  Proteasome subunit alpha type-1 from Homo sapiens

Seq: 263 a.a.

Struc: 238 a.a.

Protein chain

P25788  (PSA3_HUMAN) -  Proteasome subunit alpha type-3 from Homo sapiens

Seq: 255 a.a.

Struc: 240 a.a.

Protein chain

P28072  (PSB6_HUMAN) -  Proteasome subunit beta type-6 from Homo sapiens

Seq: 239 a.a.

Struc: 191 a.a.

Protein chain

Q99436  (PSB7_HUMAN) -  Proteasome subunit beta type-7 from Homo sapiens

Seq: 277 a.a.

Struc: 220 a.a.

Protein chain

P49720  (PSB3_HUMAN) -  Proteasome subunit beta type-3 from Homo sapiens

Seq: 205 a.a.

Struc: 204 a.a.

Protein chain

P49721  (PSB2_HUMAN) -  Proteasome subunit beta type-2 from Homo sapiens

Seq: 201 a.a.

Struc: 199 a.a.

Protein chain

P28074  (PSB5_HUMAN) -  Proteasome subunit beta type-5 from Homo sapiens

Seq: 263 a.a.

Struc: 201 a.a.

Protein chain

P20618  (PSB1_HUMAN) -  Proteasome subunit beta type-1 from Homo sapiens

Seq: 241 a.a.

Struc: 213 a.a.

Protein chain

P28070  (PSB4_HUMAN) -  Proteasome subunit beta type-4 from Homo sapiens

Seq: 264 a.a.

Struc: 215 a.a.

Protein chain

Q99460  (PSMD1_HUMAN) -  26S proteasome non-ATPase regulatory subunit 1 from Homo sapiens

Seq: 953 a.a.

Struc: 806 a.a.

Protein chain

O43242  (PSMD3_HUMAN) -  26S proteasome non-ATPase regulatory subunit 3 from Homo sapiens

Seq: 534 a.a.

Struc: 480 a.a.

Protein chain

O00232  (PSD12_HUMAN) -  26S proteasome non-ATPase regulatory subunit 12 from Homo sapiens

Seq: 456 a.a.

Struc: 456 a.a.

Protein chain

O00231  (PSD11_HUMAN) -  26S proteasome non-ATPase regulatory subunit 11 from Homo sapiens

Seq: 422 a.a.

Struc: 241 a.a.

Protein chain

Q15008  (PSMD6_HUMAN) -  26S proteasome non-ATPase regulatory subunit 6 from Homo sapiens

Seq: 389 a.a.

Struc: 378 a.a.

Protein chain

P51665  (PSMD7_HUMAN) -  26S proteasome non-ATPase regulatory subunit 7 from Homo sapiens

Seq: 324 a.a.

Struc: 286 a.a.

Protein chain

Q9UNM6  (PSD13_HUMAN) -  26S proteasome non-ATPase regulatory subunit 13 from Homo sapiens

Seq: 376 a.a.

Struc: 373 a.a.

Protein chain

P55036  (PSMD4_HUMAN) -  26S proteasome non-ATPase regulatory subunit 4 from Homo sapiens

Seq: 377 a.a.

Struc: 191 a.a.

Protein chain

O00487  (PSDE_HUMAN) -  26S proteasome non-ATPase regulatory subunit 14 from Homo sapiens

Seq: 310 a.a.

Struc: 278 a.a.

Protein chain

P48556  (PSMD8_HUMAN) -  26S proteasome non-ATPase regulatory subunit 8 from Homo sapiens

Seq: 350 a.a.

Struc: 257 a.a.

Protein chain

P60896  (SEM1_HUMAN) -  26S proteasome complex subunit SEM1 from Homo sapiens

Seq: 70 a.a.

Struc: 40 a.a.*

Protein chain

Q13200  (PSMD2_HUMAN) -  26S proteasome non-ATPase regulatory subunit 2 from Homo sapiens

Seq: 908 a.a.

Struc: 694 a.a.*

* PDB and UniProt seqs differ at 12 residue positions (black crosses)

Enzyme reactions

• Enzyme class 1: Chain c: E.C.3.4.19.- - ?????
• Enzyme class 2: Chains G, H, I, J, K, L, M, N, O, P, Q, R, S, T: E.C.3.4.25.1 - proteasome endopeptidase complex.
• Reaction: Cleavage at peptide bonds with very broad specificity.

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

DOI no: 10.1073/pnas.1614614113

Proc Natl Acad Sci U S A 113:12991-12996 (2016)

PubMed id: 27791164

Structural basis for dynamic regulation of the human 26S proteasome.

S.Chen, J.Wu, Y.Lu, Y.B.Ma, B.H.Lee, Z.Yu, Q.Ouyang, D.J.Finley, M.W.Kirschner, Y.Mao.

ABSTRACT

No abstract given.