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UniProt functional annotation for P97459 | ||
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| UniProt code: P97459. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (PubMed:27782878). {ECO:0000269|PubMed:15347806, ECO:0000269|PubMed:15635607, ECO:0000269|PubMed:27782878}. |
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| Subunit: | |
Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ARNT; forms a heterodimer that binds core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) leading to a transcriptional repressor on its target gene TH. {ECO:0000269|PubMed:15635607, ECO:0000269|PubMed:27782878}. |
| Subcellular location: | |
Nucleus. |
| Tissue specificity: | |
Expressed in brain in inhibitory interneurons. Also found in spinal cord. {ECO:0000269|PubMed:15347806}. |
| Developmental stage: | |
First detected between embryonic day 15 and day 16. |
Annotations taken from UniProtKB at the EBI.