PDBsum entry 5sxm

Transcription

PDB id: 5sxm

Contents

Protein chains

304 a.a.

Ligands

ACE-ALA-ARG-THR-GLU-VAL-TYR-NH2 ×2

Waters ×272

PDB id:

5sxm

Name:

Transcription

Title:

Wdr5 in complex with mll win motif peptidomimetic

Structure:

Wd repeat-containing protein 5. Chain: a, b. Synonym: bmp2-induced 3-kb gene protein. Engineered: yes. Ace-ala-arg-thr-glu-val-tyr-nh2. Chain: d, c. Engineered: yes. Other_details: mll win motif-derived peptidomimetic

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: wdr5, big3. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.00Å R-factor: 0.215 R-free: 0.243

Authors:

N.L.Alicea-Velazquez,S.A.Shinsky,M.S.Cosgrove

Key ref:

N.L.Alicea-Velázquez et al. (2016). Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes. J Biol Chem, 291, 22357-22372. PubMed id: 27563068 DOI: 10.1074/jbc.M116.752626

Date:

09-Aug-16 Release date: 07-Sep-16

Protein chains

P61964  (WDR5_HUMAN) -  WD repeat-containing protein 5 from Homo sapiens

Seq: 334 a.a.

Struc: 304 a.a.

DOI no: 10.1074/jbc.M116.752626

J Biol Chem 291:22357-22372 (2016)

PubMed id: 27563068

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

N.L.Alicea-Velázquez, S.A.Shinsky, D.M.Loh, J.H.Lee, D.G.Skalnik, M.S.Cosgrove.

ABSTRACT

No abstract given.