UniProt functional annotation for P00760

UniProt code: P00760.

Organism: Bos taurus (Bovine).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
 
Catalytic activity: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
Cofactor: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
Subcellular location: Secreted, extracellular space.
Tissue specificity: Synthesized in the acinar cells of the pancreas.
Ptm: Autocatalytic cleavage after Lys-23 leads to beta-trypsin by releasing a terminal hexapeptide. Subsequent cleavage after Lys- 148 leads to alpha-trypsin. Further cleavage after Lys-193 yields pseudotrypsin. A cleavage may also occur after Arg-122.
Ptm: Not sulfated on tyrosine residue(s).
Similarity: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-ProRule:PRU00274}.
Similarity: Contains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule:PRU00274}.

Annotations taken from UniProtKB at the EBI.