|
|
||
|
|
|
|
|
UniProt functional annotation for P00791 | ||
|
|
|
|
|
|
||
| UniProt code: P00791. |
|
||
| Organism: | |
Sus scrofa (Pig). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. |
|
||
|
||
| Function: | |
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. |
|
||
| Catalytic activity: | |
Reaction=Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His- 5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu- 17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.; EC=3.4.23.1; Evidence={ECO:0000255|PROSITE- ProRule:PRU10094}; |
| Subcellular location: | |
Secreted. |
| Ptm: | |
Minor amounts of the active enzyme occur with 'Ala-58' at the amino end. |
| Similarity: | |
Belongs to the peptidase A1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.