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UniProt functional annotation for Q8NI77 | ||
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| UniProt code: Q8NI77. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}. |
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| Subunit: | |
Interacts with CENPE and ESR1. {ECO:0000269|PubMed:17006958, ECO:0000269|PubMed:19625775, ECO:0000269|PubMed:19636373}. |
| Subcellular location: | |
Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. |
| Induction: | |
By estrogen. {ECO:0000269|PubMed:19636373}. |
| Ptm: | |
Glycosylated. {ECO:0000269|PubMed:18680169}. |
| Ptm: | |
Ubiquitinated. {ECO:0000269|PubMed:18680169}. |
| Similarity: | |
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}. |
Annotations taken from UniProtKB at the EBI.