PDBsum entry 5luu

Transcription

PDB id: 5luu

Contents

Protein chain

127 a.a.

Ligands

EDO ×2

77X

Waters ×191

PDB id:

5luu

Name:

Transcription

Title:

Structure of the first bromodomain of brd4 with a pyrazolo[4,3- c]pyridin fragment

Structure:

Bromodomain-containing protein 4. Chain: a. Synonym: protein hunk1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: brd4, hunk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.61Å R-factor: 0.171 R-free: 0.206

Authors:

P.Filippakopoulos,S.Picaud,S.Knapp,F.Von Delft,C.Bountra, C.H.Arrowsmith,A.Edwards,Structural Genomics Consortium (Sgc)

Key ref:

I.Navratilova et al. (2016). Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening. Acs Med Chem Lett, 7, 1213-1218. PubMed id: 27994766 DOI: 10.1021/acsmedchemlett.6b00154

Date:

11-Sep-16 Release date: 12-Oct-16

Protein chain

O60885  (BRD4_HUMAN) -  Bromodomain-containing protein 4 from Homo sapiens

Seq: 1362 a.a.

Struc: 127 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.?

DOI no: 10.1021/acsmedchemlett.6b00154

Acs Med Chem Lett 7:1213-1218 (2016)

PubMed id: 27994766

Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.

I.Navratilova, T.Aristotelous, S.Picaud, A.Chaikuad, S.Knapp, P.Filappakopoulos, A.L.Hopkins.

ABSTRACT

No abstract given.