PDBsum entry 5lnp

Signaling protein

PDB id: 5lnp

Contents

Protein chains

94 a.a.

94 a.a.

Ligands

SO4

Waters ×33

PDB id:

5lnp

Name:

Signaling protein

Title:

Domain-swapped dimer of human dishevelled2 dep domain: monoclinic crystal form crystallised from monomeric fraction

Structure:

Segment polarity protein dishevelled homolog dvl-2. Chain: a, c, d. Fragment: dep domain, unp residues 416-510. Synonym: dishevelled-2,dsh homolog 2. Engineered: yes. Segment polarity protein dishevelled homolog dvl-2. Chain: b. Fragment: dep domain, unp residues 416-510. Synonym: dishevelled-2,dsh homolog 2.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dvl2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.99Å R-factor: 0.196 R-free: 0.246

Authors:

M.Renko,M.V.Gammons,M.Bienz

Key ref:

M.V.Gammons et al. (2016). Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled. Mol Cell, 64, 92. PubMed id: 27692984 DOI: 10.1016/j.molcel.2016.08.026

Date:

05-Aug-16 Release date: 12-Oct-16

Protein chains

O14641  (DVL2_HUMAN) -  Segment polarity protein dishevelled homolog DVL-2 from Homo sapiens

Seq: 736 a.a.

Struc: 94 a.a.*

Protein chain

O14641  (DVL2_HUMAN) -  Segment polarity protein dishevelled homolog DVL-2 from Homo sapiens

Seq: 736 a.a.

Struc: 94 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

DOI no: 10.1016/j.molcel.2016.08.026

Mol Cell 64:92 (2016)

PubMed id: 27692984

Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled.

M.V.Gammons, M.Renko, C.M.Johnson, T.J.Rutherford, M.Bienz.

ABSTRACT

No abstract given.