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UniProt functional annotation for P30260 | ||
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| UniProt code: P30260. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}. |
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| Pathway: | |
Protein modification; protein ubiquitination. |
| Subunit: | |
Homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:26083744, PubMed:25043029). Interacts with RB. Interacts with FAM168B/MANI (By similarity). Interacts with MCPH1 (PubMed:22139841). {ECO:0000250, ECO:0000250|UniProtKB:A2A6Q5, ECO:0000269|PubMed:22139841, ECO:0000269|PubMed:25043029, ECO:0000269|PubMed:26083744}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. |
| Ptm: | |
Phosphorylated. Phosphorylation on Ser-426 and Thr-446 occurs specifically during mitosis. {ECO:0000269|PubMed:14657031, ECO:0000269|PubMed:22139841}. |
| Miscellaneous: | |
[Isoform 2]: May be due to competing acceptor splice site. {ECO:0000305}. |
| Similarity: | |
Belongs to the APC3/CDC27 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.