PDBsum entry 5l99

Transcription

PDB id: 5l99

Contents

Protein chain

116 a.a.

Ligands

6S0

Waters ×99

PDB id:

5l99

Name:

Transcription

Title:

Crystal structure of baz2b bromodomain in complex with 3-amino-2- methylpyridine derivative 6

Structure:

Bromodomain adjacent to zinc finger domain protein 2b. Chain: a. Fragment: bromodomain (residues 2054-2168). Synonym: hwalp4. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: baz2b, kiaa1476. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.00Å R-factor: 0.179 R-free: 0.204

Authors:

G.Lolli,J.-R.Marchand,A.Caflisch

Key ref:

J.R.Marchand et al. (2016). Derivatives of 3-Amino-2-methylpyridine as BAZ2B Bromodomain Ligands: In Silico Discovery and in Crystallo Validation. J Med Chem, 59, 9919-9927. PubMed id: 27731638 DOI: 10.1021/acs.jmedchem.6b01258

Date:

09-Jun-16 Release date: 26-Oct-16

Protein chain

Q9UIF8  (BAZ2B_HUMAN) -  Bromodomain adjacent to zinc finger domain protein 2B from Homo sapiens

Seq: 2168 a.a.

Struc: 116 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

DOI no: 10.1021/acs.jmedchem.6b01258

J Med Chem 59:9919-9927 (2016)

PubMed id: 27731638

Derivatives of 3-Amino-2-methylpyridine as BAZ2B Bromodomain Ligands: In Silico Discovery and in Crystallo Validation.

J.R.Marchand, G.Lolli, A.Caflisch.

ABSTRACT

No abstract given.