PDBsum entry 5l97

Transcription

PDB id

5l97

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Contents

			Protein chain

					116 a.a.

			Ligands

					6RW

			Waters ×91

PDB id:

5l97

Links

Name:

Transcription

Title:

Crystal structure of baz2b bromodomain in complex with 3-amino-2- methylpyridine derivative 3

Structure:

Bromodomain adjacent to zinc finger domain protein 2b. Chain: a. Fragment: bromodomain (residues 2054-2168). Synonym: hwalp4. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: baz2b, kiaa1476. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.05Å

R-factor:

0.184

R-free:

0.211

Authors:

G.Lolli,J.-R.Marchand,A.Caflisch

Key ref:

J.R.Marchand et al. (2016). Derivatives of 3-Amino-2-methylpyridine as BAZ2B Bromodomain Ligands: In Silico Discovery and in Crystallo Validation. J Med Chem, 59, 9919-9927. PubMed id: 27731638 DOI: 10.1021/acs.jmedchem.6b01258

Date:

09-Jun-16

Release date:

26-Oct-16

PROCHECK

	Headers

	References

Protein chain

Q9UIF8 (BAZ2B_HUMAN) - Bromodomain adjacent to zinc finger domain protein 2B from Homo sapiens

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:					2168 a.a. 116 a.a.*

Key:

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

DOI no: 10.1021/acs.jmedchem.6b01258	J Med Chem 59:9919-9927 (2016)
PubMed id: 27731638

Derivatives of 3-Amino-2-methylpyridine as BAZ2B Bromodomain Ligands: In Silico Discovery and in Crystallo Validation.
J.R.Marchand, G.Lolli, A.Caflisch.

ABSTRACT

No abstract given.