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UniProt functional annotation for P62068 | ||
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| UniProt code: P62068. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). {ECO:0000250|UniProtKB:P62069, ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:26388029}. |
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| Catalytic activity: | |
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000269|PubMed:14715245, ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:26388029}; |
| Activity regulation: | |
Activated by interaction with WDR48. {ECO:0000269|PubMed:26388029}. |
| Subunit: | |
Interacts with WDR48 (PubMed:19075014, PubMed:26388029). Interacts with WDR20 (PubMed:20147737). {ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:26388029}. |
| Tissue specificity: | |
Broadly expressed. {ECO:0000269|PubMed:14715245}. |
| Similarity: | |
Belongs to the peptidase C19 family. USP12/USP46 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.