UniProt functional annotation for P70207



	UniProt functional annotation for P70207

UniProt code: P70207.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. {ECO:0000269|PubMed:10520994, ECO:0000269|PubMed:10781943, ECO:0000269|PubMed:20877282}.

Subunit: Homodimer. Interacts with RND1 (By similarity). Interacts directly with NRP1 and NRP2. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. {ECO:0000250, ECO:0000269|PubMed:10520994, ECO:0000269|PubMed:10781943, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:20881961}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:20881961}; Single-pass type I membrane protein {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:20881961}.

Similarity: Belongs to the plexin family. {ECO:0000305}.

Sequence caution: Sequence=AAH68155.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA13189.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. {ECO:0000269\|PubMed:10520994, ECO:0000269\|PubMed:10781943, ECO:0000269\|PubMed:20877282}.


Subunit:		Homodimer. Interacts with RND1 (By similarity). Interacts directly with NRP1 and NRP2. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. {ECO:0000250, ECO:0000269\|PubMed:10520994, ECO:0000269\|PubMed:10781943, ECO:0000269\|PubMed:20877282, ECO:0000269\|PubMed:20881961}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:20877282, ECO:0000269\|PubMed:20881961}; Single-pass type I membrane protein {ECO:0000269\|PubMed:20877282, ECO:0000269\|PubMed:20881961}.
Similarity:		Belongs to the plexin family. {ECO:0000305}.
Sequence caution:		Sequence=AAH68155.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA13189.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};