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UniProt functional annotation for P70206 | ||
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| UniProt code: P70206. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. {ECO:0000269|PubMed:10520994, ECO:0000269|PubMed:10781943}. |
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| Subunit: | |
Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Interacts with CRMP1, DPYSL2/CRMP2, DPYSL3/CRMP3 and DPYSL4/CRMP4. {ECO:0000269|PubMed:10520994, ECO:0000269|PubMed:10781943, ECO:0000269|PubMed:12559962, ECO:0000269|PubMed:14685275, ECO:0000269|PubMed:14977921, ECO:0000269|PubMed:16286926}. |
| Subcellular location: | |
Cell membrane; Single-pass type I membrane protein. |
| Tissue specificity: | |
Ubiquitous. {ECO:0000269|PubMed:12559962, ECO:0000269|PubMed:8806667}. |
| Similarity: | |
Belongs to the plexin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.