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UniProt functional annotation for Q13905 | ||
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| UniProt code: Q13905. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
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| Subunit: | |
Interacts with HCK (via SH3-binding sites) (PubMed:14551197). Interacts with CRK (via SH3-binding sites) (PubMed:8662907). {ECO:0000269|PubMed:14551197, ECO:0000269|PubMed:8662907}. |
| Subcellular location: | |
Early endosome {ECO:0000269|PubMed:17724123}. |
| Tissue specificity: | |
Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver. |
| Ptm: | |
Phosphorylation at Tyr-504 enhances activity as Rap guanine nucleotide exchange factor. {ECO:0000269|PubMed:14551197}. |
Annotations taken from UniProtKB at the EBI.