UniProt functional annotation for Q8IXI2



	UniProt functional annotation for Q8IXI2

UniProt code: Q8IXI2.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657). {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657}.

Subunit: Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules (PubMed:16630562). Interacts with ARMCX1 (By similarity). Found in a complex with KIF5B, OGT, RHOT2 and TRAK1 (PubMed:24995978). {ECO:0000250|UniProtKB:Q8BG51, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:24995978}.

Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.

Tissue specificity: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. {ECO:0000269|PubMed:12482879}.

Ptm: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy (PubMed:22396657, PubMed:24896179). Deubiquitinated by USP30 (PubMed:24896179). {ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:24896179}.

Similarity: Belongs to the mitochondrial Rho GTPase family. {ECO:0000255|PROSITE-ProRule:PRU00757, ECO:0000305}.

Sequence caution: Sequence=AAH41114.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH68463.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14185.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657). {ECO:0000269\|PubMed:12482879, ECO:0000269\|PubMed:16630562, ECO:0000269\|PubMed:22396657}.


Subunit:		Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules (PubMed:16630562). Interacts with ARMCX1 (By similarity). Found in a complex with KIF5B, OGT, RHOT2 and TRAK1 (PubMed:24995978). {ECO:0000250\|UniProtKB:Q8BG51, ECO:0000269\|PubMed:16630562, ECO:0000269\|PubMed:24995978}.
Subcellular location:		Mitochondrion outer membrane {ECO:0000269\|PubMed:12482879, ECO:0000269\|PubMed:19528298}; Single-pass type IV membrane protein {ECO:0000269\|PubMed:12482879, ECO:0000269\|PubMed:19528298}. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.
Tissue specificity:		Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. {ECO:0000269\|PubMed:12482879}.
Ptm:		Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy (PubMed:22396657, PubMed:24896179). Deubiquitinated by USP30 (PubMed:24896179). {ECO:0000269\|PubMed:22396657, ECO:0000269\|PubMed:24896179}.
Similarity:		Belongs to the mitochondrial Rho GTPase family. {ECO:0000255\|PROSITE-ProRule:PRU00757, ECO:0000305}.
Sequence caution:		Sequence=AAH41114.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH68463.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14185.1; Type=Erroneous initiation; Evidence={ECO:0000305};