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PDBsum entry 5kn5
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protein ligands metals Protein-protein interface(s) links
Immune system PDB id
5kn5

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
214 a.a.
216 a.a.
40 a.a.
39 a.a.
Ligands
SO4
Metals
_ZN
Waters ×150
PDB id:
5kn5
Name: Immune system
Title: Tgfalpha/epiregulin complex with neutralizing antibody ly3016859
Structure: Epiregulin antibody ly3016859 fab heavy chain. Chain: a, d. Engineered: yes. Epiregulin antibody ly3016859 fab light chain. Chain: b, e. Engineered: yes. Protransforming growth factor alpha. Chain: c, f. Engineered: yes
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic: yes. Human. Organism_taxid: 9606
Resolution:
2.80Å     R-factor:   0.206     R-free:   0.263
Authors: S.Atwell,J.S.Boyles,D.K.Clawson,Z.Druzina,G.H.Josef,K.Weichert, D.R.Witcher
Key ref: J.S.Boyles et al. (2016). Structural basis of selectivity and neutralizing activity of a TGFα/epiregulin specific antibody. Protein Sci, 25, 2028-2036. PubMed id: 27543934 DOI: 10.1002/pro.3023
Date:
27-Jun-16     Release date:   31-Aug-16    
PROCHECK
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 Headers
 References

Protein chains
No UniProt id for this chain
Struc: 214 a.a.
Protein chains
No UniProt id for this chain
Struc: 216 a.a.
Protein chain
Pfam   ArchSchema ?
P01135  (TGFA_HUMAN) -  Protransforming growth factor alpha from Homo sapiens
Seq:
Struc: 		160 a.a.
40 a.a.
Protein chain
Pfam   ArchSchema ?
P01135  (TGFA_HUMAN) -  Protransforming growth factor alpha from Homo sapiens
Seq:
Struc: 		160 a.a.
39 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 

 
DOI no: 10.1002/pro.3023 Protein Sci 25:2028-2036 (2016)
PubMed id: 27543934  
 
 
Structural basis of selectivity and neutralizing activity of a TGFα/epiregulin specific antibody.
J.S.Boyles, S.Atwell, Z.Druzina, J.G.Heuer, D.R.Witcher.
 
  ABSTRACT  
 
No abstract given.

 

 

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