|
|
||
|
|
|
|
|
UniProt functional annotation for P63025 | ||
|
|
|
|
|
|
||
| UniProt code: P63025. |
|
||
| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
|
||
|
||
| Function: | |
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000250}. |
|
||
| Subunit: | |
Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum (By similarity). Interacts with BAIAP3; this interaction is increased in the presence of calcium (By similarity). Interacts with PICALM (By similarity). {ECO:0000250|UniProtKB:P63024, ECO:0000250|UniProtKB:Q15836}. |
| Subcellular location: | |
Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}. |
| Tissue specificity: | |
Ubiquitous. |
| Ptm: | |
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 46-Lys-|-Leu-47 bond and probably inhibits neurotransmitter release (PubMed:8175689). {ECO:0000269|PubMed:8175689}. |
| Ptm: | |
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 45-Gln-|-Lys-46 bond and probably inhibits neurotransmitter release (PubMed:8175689). {ECO:0000269|PubMed:8175689}. |
| Ptm: | |
(Microbial infection) Targeted and hydrolyzed by C.tetani toxin (tetX) which hydrolyzes the 63-Gln-|-Phe-64 bond and probably inhibits neurotransmitter release (PubMed:8175689). {ECO:0000269|PubMed:8175689}. |
| Similarity: | |
Belongs to the synaptobrevin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.