PDBsum entry 5kcw

Transcription

PDB id: 5kcw

Contents

Protein chains

233 a.a.

Ligands

HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP

LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP

OB9

OB9-OB9

Waters ×139

PDB id:

5kcw

Name:

Transcription

Title:

Crystal structure of the er-alpha ligand-binding domain (y537s) in complex with an n-trifluoroethyl obhs-n derivative

Structure:

Estrogen receptor. Chain: a, b. Fragment: ligand-binding domain. Synonym: er,er-alpha,estradiol receptor,nuclear receptor subfamily 3 group a member 1. Engineered: yes. Mutation: yes. Ncoa2. Chain: c, d.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: esr1, esr, nr3a1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence occurs naturally in humans

Resolution:

1.91Å R-factor: 0.193 R-free: 0.246

Authors:

J.C.Nwachukwu,S.Srinivasan,N.E.Bruno,V.Dharmarajan,D.Goswami, I.Kastrati,S.Novick,J.Nowak,H.B.Zhou,N.Boonmuen,Y.Zhao,J.Min, J.Frasor,B.S.Katzenellenbogen,P.R.Griffin,J.A.Katzenellenbogen, K.W.Nettles

Key ref:

S.Srinivasan et al. (2017). Full antagonism of the estrogen receptor without a prototypical ligand side chain. Nat Chem Biol, 13, 111-118. PubMed id: 27870835 DOI: 10.1038/nchembio.2236

Date:

07-Jun-16 Release date: 16-Nov-16

Supersedes:

5bpr

Protein chains

P03372  (ESR1_HUMAN) -  Estrogen receptor from Homo sapiens

Seq: 595 a.a.

Struc: 233 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.?

DOI no: 10.1038/nchembio.2236

Nat Chem Biol 13:111-118 (2017)

PubMed id: 27870835

Full antagonism of the estrogen receptor without a prototypical ligand side chain.

S.Srinivasan, J.C.Nwachukwu, N.E.Bruno, V.Dharmarajan, D.Goswami, I.Kastrati, S.Novick, J.Nowak, V.Cavett, H.B.Zhou, N.Boonmuen, Y.Zhao, J.Min, J.Frasor, B.S.Katzenellenbogen, P.R.Griffin, J.A.Katzenellenbogen, K.W.Nettles.

ABSTRACT

No abstract given.