PDBsum entry 5k8k

Hydrolase

PDB id: 5k8k

Contents

Protein chain

237 a.a.

Ligands

LP5

ACT ×2

GOL ×2

Metals

_MN ×2

Waters ×19

PDB id:

5k8k

Name:

Hydrolase

Title:

Structure of the haemophilus influenzae lpxh-lipid x complex

Structure:

Udp-2,3-diacylglucosamine hydrolase. Chain: a. Synonym: udp-2,3-diacylglucosamine diphosphatase. Engineered: yes

Source:

Haemophilus influenzae (strain atcc 51907 / dsm 11121 / kw20 / rd). Organism_taxid: 71421. Strain: atcc 51907 / dsm 11121 / kw20 / rd. Gene: lpxh, hi_0735. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.55Å R-factor: 0.195 R-free: 0.227

Authors:

J.Cho,C.-J.Lee,P.Zhou

Key ref:

J.Cho et al. (2016). Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis. Nat Microbiol, 1, 16154. PubMed id: 27780190 DOI: 10.1038/nmicrobiol.2016.154

Date:

30-May-16 Release date: 10-Aug-16

Protein chain

P44046  (LPXH_HAEIN) -  UDP-2,3-diacylglucosamine hydrolase from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Seq: 237 a.a.

Struc: 237 a.a.

Enzyme reactions

• Enzyme class: E.C.3.6.1.54 - UDP-2,3-diacylglucosamine diphosphatase.
• Reaction: a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O = a lipid X + UMP + 2 H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1038/nmicrobiol.2016.154

Nat Microbiol 1:16154 (2016)

PubMed id: 27780190

Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis.

J.Cho, C.J.Lee, J.Zhao, H.E.Young, P.Zhou.

ABSTRACT

No abstract given.