UniProt functional annotation for Q6V4S5



	UniProt functional annotation for Q6V4S5

UniProt code: Q6V4S5.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion (PubMed:26287463). Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion (PubMed:26287463). Promotes synaptic connectivity via homophilic interactions (PubMed:26287463). {ECO:0000269|PubMed:26287463}.

Subunit: Homodimer; mediates homophilic interactions to promote cell adhesion (PubMed:15703275, PubMed:26287463). Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4 (PubMed:20219992). {ECO:0000269|PubMed:15703275, ECO:0000269|PubMed:20219992, ECO:0000269|PubMed:26287463}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8AV57}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8AV57}. Cell junction, synapse {ECO:0000269|PubMed:20219992, ECO:0000305|PubMed:26287463}.

Tissue specificity: Expressed in retinal ganglion cells (RGCs) that form synapses in distinct inner plexiform layer (IPL) sublaminae. Specifically expressed in specific subsets of retinal ganglion cells (RGCs), named W3B-RGCs, that specifically respond when the timing of the movement of a small object differs from that of the background, but not when they coincide (at protein level). Also present in excitatory amacrine cell type called VG3-ACs, that provide strong and selective input W3B-RGCs (at protein level) (PubMed:26287463). Expressed at low levels in the glomeruli (PubMed:15213259). {ECO:0000269|PubMed:15213259, ECO:0000269|PubMed:26287463}.

Developmental stage: Highly expressed in many fetal tissues, inlcuding kidney but shows markedly lower expression in adult organs. Expression in kidney is high throughout development with maximal expression occurring near birth. {ECO:0000269|PubMed:15213259}.

Domain: the PDZ-binding motif mediates interaction with PDZ domain- containing proteins MAGI1, MAGI2, DLG2, DLG3 and DLG4 and is required for is required for synaptic localization in photoreceptors. {ECO:0000269|PubMed:20219992}.

Disruption phenotype: Mice are viable and fertile but show decreased synaptic connectivity between the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. {ECO:0000269|PubMed:26287463}.

Miscellaneous: [Isoform 3]: Due to intron retention. {ECO:0000305}.

Similarity: Belongs to the sidekick family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion (PubMed:26287463). Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion (PubMed:26287463). Promotes synaptic connectivity via homophilic interactions (PubMed:26287463). {ECO:0000269\|PubMed:26287463}.


Subunit:		Homodimer; mediates homophilic interactions to promote cell adhesion (PubMed:15703275, PubMed:26287463). Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4 (PubMed:20219992). {ECO:0000269\|PubMed:15703275, ECO:0000269\|PubMed:20219992, ECO:0000269\|PubMed:26287463}.
Subcellular location:		Cell membrane {ECO:0000250\|UniProtKB:Q8AV57}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:Q8AV57}. Cell junction, synapse {ECO:0000269\|PubMed:20219992, ECO:0000305\|PubMed:26287463}.
Tissue specificity:		Expressed in retinal ganglion cells (RGCs) that form synapses in distinct inner plexiform layer (IPL) sublaminae. Specifically expressed in specific subsets of retinal ganglion cells (RGCs), named W3B-RGCs, that specifically respond when the timing of the movement of a small object differs from that of the background, but not when they coincide (at protein level). Also present in excitatory amacrine cell type called VG3-ACs, that provide strong and selective input W3B-RGCs (at protein level) (PubMed:26287463). Expressed at low levels in the glomeruli (PubMed:15213259). {ECO:0000269\|PubMed:15213259, ECO:0000269\|PubMed:26287463}.
Developmental stage:		Highly expressed in many fetal tissues, inlcuding kidney but shows markedly lower expression in adult organs. Expression in kidney is high throughout development with maximal expression occurring near birth. {ECO:0000269\|PubMed:15213259}.
Domain:		the PDZ-binding motif mediates interaction with PDZ domain- containing proteins MAGI1, MAGI2, DLG2, DLG3 and DLG4 and is required for is required for synaptic localization in photoreceptors. {ECO:0000269\|PubMed:20219992}.
Disruption phenotype:		Mice are viable and fertile but show decreased synaptic connectivity between the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. {ECO:0000269\|PubMed:26287463}.
Miscellaneous:		[Isoform 3]: Due to intron retention. {ECO:0000305}.
Similarity:		Belongs to the sidekick family. {ECO:0000305}.